Seed's morphology-induced core-shell composite particles by seeded emulsion polymerization for drug delivery

摘要

Cross-liked poly(2-hydroxyethyl methacrylate-co-methacrylic acid) seeds with different morphologies such as cauliflower-like, lobed spherical, and spherical were used in seeded emulsion polymerization (SEP) of 2-(dimethylamino)ethyl methacrylate (DMAEMA), 2-hydroxyethyl methacrylate (HEMA), and methacrylic acid (MAA). The morphological structure of produced composite particles was observed using field emission scanning electron microscopy (FE-SEM). The origin of the formation of different morphologies was discussed using various thermodynamic parameters such as solubility parameters and intermolecular forces between polymeric components involved. Also, the effect of the morphology of seed particles on the resultant structures was investigated. Results showed that morphology of fabricated composite particles is induced from morphology of seed particles with larger sizes. Finally, the fabricated composite particles were utilized in the controlled release of DOX. The effect of morphological changes of synthesized composite particles on the cumulative release behavior at acidic environment indicated the pH-sensitive nature of drug release through carriers. The particles with PDMAEMA shell showed the highest release of DOX at pH = 7.4 whereas PMAA shells displayed the least cumulative release. Inversely, the lowest cumulative release at pH = 1.2 was shown by PDMAEMA-coated carriers. Moreover, particles with spherical morphology had better drug release than cauliflower-like ones originated from smart nature of carriers.