Synthesis and characterization of magnetized-PEGylated dendrimer anchored to thermosensitive polymer for letrozole drug delivery

摘要

Letrozole as a target loaded drug on siliceous magnetized Fe3O4 nanoparticles grafted with high-branched dendrimers. Grafted polymer coating contained N-vinyl caprolactam as a stimulus-responsive polymer which functionalized with five generations of dendrimers containing oxime functional group. The precursors underwent PEGylating polymerization to form PEGylated dendrimer coating on the particle surface as the final carrier. The final product has the average size of 79 nm. The final product characterized by FT-IR, TGA, VSM, SEM-EDAX to investigate carrier features further. Some characteristic parameters in adsorption process like pH, time, the temperature investigated for letrozole using the final carrier. The physical and chemical properties of the final polymerized generations were also studied. Letrozole releasing process examined in the simulated intestinal fluid (pH = 7.4) revealed 95% of letrozole released during 25 h which also considered by Korsmeyer-Peppas equation to verify Fickian diffusion mechanism.