Neuroendocrine Differentiation, Microsatellite Instability, and Tumor-infiltrating Lymphocytes in Advanced Colorectal Cancer With BRAF Mutation

摘要

A clinicopathologic analysis of 59 cases of advanced colorectal cancer with BRAF mutation was performed to compare microsatellite unstable and stable cases, focusing on the inflammatory profiles and neuroendocrine differentiation of these tumors. Microsatellite stable tumors showed a high frequency of neuroendocrine differentiation. The combined presence of microsatellite instability and high CD8 T-cell content was associated with a 63% reduction in the risk of death.