Skin inflammation induced by lupus serum was inhibited in IL-1R deficient mice

摘要

Skin inflammation induced by lupus serum is a useful tool to investigate the pathogenesis of lupus skin injury. IL-1 is a proinflammatory cytoldne, and its role in lupus skin lesion is still unclear. We determined the role of IL-1 in lupus skin injury by using gene deficient mice. We found that skin inflammation induced by lupus serum was significantly reduced in IL-1R deficient mice and caspase-1 deficient mice. IL-1R deficiency did not affect the expression of Fc gamma RI (CD64), Fc gamma RII (CD32) and MHC class II (CD74) induced by lupus serum. IL-1R deficiency reduced the lipid raft clustering, and decreased expression of MCP-1 and TNF alpha. in monocytes. Keratinocyte proliferation induced by lupus serum was significantly decreased in TNF alpha deficient mice. Our findings indicate that IL-1 plays an important role in skin lesions of SLE. This study suggests that IL-1 is a therapeutic target in skin lesions of SLE. (C) 2017 Elsevier Inc. Affrights reserved.