Hydroxychloroquine as a novel therapeutic approach in mast cell activation diseases

摘要

There is no therapeutic agent approved in cutaneous mastocytosis and mast cell activation syndrome. We report the efficacy ofhydroxychloroquinein four patients with cutaneous mastocytosis (n?=?2) and mast cell activation syndrome (n?=?2).We show that this molecule reduces the long-term survival of primary human mast cells, interferes with lysosome function and leads to the accumulation of non-functional tryptase in the mast cell granules. Furthermore,hydroxychloroquinedecreases the production of pro-inflammatory mediators.