Quantitative diffusion-weighted magnetic resonance imaging assessment of chemotherapy treatment response of pediatric osteosarcoma and Ewing sarcoma malignant bone tumors

摘要

Abstract Objective Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection. Subjects and methods Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers. Results Treated tumors demonstrated significantly greater ADC values compared to untreated tumors ( p Conclusions Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors. Highlights ? Apparent diffusion coefficient values within pediatric bone tumors increase substantially following chemotherapy. ? Physical tumor measurements alone may not always accurately reflect treatment response. ? The average apparent diffusion coefficient value best predicts treatment status.