Serum anti-TOPO48 autoantibody as a biomarker for early diagnosis and prognosis in patients with esophageal squamous cell carcinoma

摘要

Background and aim: We previously reported a novel tumor associated antigen (TTA) with molecular weight around 48 kDa that is a fragment derived from human DNA-topoiomerase I (TOP1). We termed the novel TM as TOPO48 and termed autoantibody against the TAA as anti-TOPO48 autoantibody. The aim of this study is to further investigate the clinical applications of the autoantibody in patients with esophageal squamous cell carcinomas (ESCC).