Dendrobium nobile Lindl alkaloid, a novel autophagy inducer, protects against axonal degeneration induced by A(25-35) in hippocampus neurons in vitro

摘要

AimsAxonal degeneration is a pathological symbol in the early stage of Alzheimer's disease (AD), which can be triggered by amyloid- (A) peptide deposition. Growing evidence indicates that deficit of autophagy eventually leads to the axonal degeneration. Our previous studies have shown that Dendrobium nobile Lindl alkaloid (DNLA) had protective effect on neuron impairment in vivo and in vitro; however, the underlying mechanisms is still unclear.