POPULATION PHARMACOKINETICS (POPPK) OF RG7827 (FAP-4-1BBL), A NOVEL BISPECIFIC FUSION PROTEIN TARGETING FIBROBLAST ACTIVATION PROTEIN (FAP) AND 4-1BB LIGAND (4-1BBL), IN SOLID TUMOR CANCER PATIENTS.

Morcos P.; Frey N.; Buchheit V.; Canadi J.; Klein C.; Claus C.; Guarin E.; Chick J.; Krieter O.; Djebli N.

首页> 外文期刊>Clinical Pharmacology and Therapeutics >POPULATION PHARMACOKINETICS (POPPK) OF RG7827 (FAP-4-1BBL), A NOVEL BISPECIFIC FUSION PROTEIN TARGETING FIBROBLAST ACTIVATION PROTEIN (FAP) AND 4-1BB LIGAND (4-1BBL), IN SOLID TUMOR CANCER PATIENTS.

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POPULATION PHARMACOKINETICS (POPPK) OF RG7827 (FAP-4-1BBL), A NOVEL BISPECIFIC FUSION PROTEIN TARGETING FIBROBLAST ACTIVATION PROTEIN (FAP) AND 4-1BB LIGAND (4-1BBL), IN SOLID TUMOR CANCER PATIENTS.

机译：RG7827的人口药代动力学（POPPK）（FAP-4-1BBL），一种新的双特异性融合蛋白靶向成纤维细胞活化蛋白（FAP）和4-1BB配体（4-1BBL），在实体瘤癌症患者中。

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来源
《Clinical Pharmacology and Therapeutics》 |2020年第s1期|共1页
作者
Morcos P.; Frey N.; Buchheit V.; Canadi J.; Klein C.; Claus C.; Guarin E.; Chick J.; Krieter O.; Djebli N.;
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Roche New York NY USA;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

Roche Basel Switzerland;

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正文语种 eng
中图分类药理学;
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专利

1. POPULATION PHARMACOKINETICS (POPPK) OF RG7827 (FAP-4-1BBL), A NOVEL BISPECIFIC FUSION PROTEIN TARGETING FIBROBLAST ACTIVATION PROTEIN (FAP) AND 4-1BB LIGAND (4-1BBL), IN SOLID TUMOR CANCER PATIENTS. [J] . Morcos P., Frey N., Buchheit V., Clinical Pharmacology and Therapeutics . 2020,第S1期

机译：RG7827的人口药代动力学（POPPK）（FAP-4-1BBL），一种新的双特异性融合蛋白靶向成纤维细胞活化蛋白（FAP）和4-1BB配体（4-1BBL），在实体瘤癌症患者中。
2. A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer [J] . Cao Hai-Ying, Guo Xiao-Fang, Zhu Xia-Fei, Oncology reports . 2017,第6期

机译：基于配体和Enediyne-energized双特异性融合蛋白靶向表皮生长因子受体和胰岛素样生长因子-1受体显示出对食管癌的有效抗肿瘤功效
3. Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously [J] . Rabenhold Markus, Steiniger Frank, Fahr Alfred, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2015,第Null期

机译：同时靶向内皮糖蛋白（CD105）和成纤维细胞活化蛋白（FAP）的双特异性单链双抗体免疫脂质体
4. Targeted Costimulation with Novel Single-Chain 4-1BBL or OX40L Antibody-Fusion Proteins Promotes Tumor Directed T Cell Activation [C] . Sina Fellermeier, Jan-Erik Meyer, Stefan Bader, PEGS . 2015

机译：具有新型单链4-1BBL或OX40L抗体融合蛋白的靶向共刺激促进了肿瘤指导的T细胞活化
5. Targeting carcinoma-associated fibroblasts (CAFs) with a fibroblast activation protein (FAP)-activated prodrug chemotherapy [D] . Brennen, W. Nathaniel 2011

机译：用成纤维细胞活化蛋白（FAP）激活的前药化疗靶向癌相关的成纤维细胞（CAF）
6. Targeting the Tumor Microenvironment with Fluorescence-Activatable Bispecific Endoglin/Fibroblast Activation Protein Targeting Liposomes [O] . Felista L. Tansi, Ronny Rüger, Ansgar M. Kollmeier, 2020

机译：靶向荧光激活双特异性内皮糖蛋白/成纤维细胞活化蛋白靶向脂质体的肿瘤微环境。
7. Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice [O] . Elizabeth K. Duperret, Aspen Trautz, Dylan Ammons, 2017

机译：使用共有DNA疫苗靶向成纤维细胞活化蛋白（FAP）的肿瘤基质改变与小鼠抗肿瘤疫苗治疗协同

POPULATION PHARMACOKINETICS (POPPK) OF RG7827 (FAP-4-1BBL), A NOVEL BISPECIFIC FUSION PROTEIN TARGETING FIBROBLAST ACTIVATION PROTEIN (FAP) AND 4-1BB LIGAND (4-1BBL), IN SOLID TUMOR CANCER PATIENTS.

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