POPULATION PHARMACOKINETICS OF VOLANESORSEN, AN ANTISENSE OLIGONUCLEOTIDE TARGETING HUMAN APOLIPOPROTEIN C-III, IN HEALTHY SUBJECTS AND PATIENTS WITH FAMILIAL CHYLOMICRONEMIA SYNDROME OR HYPERTRIGLYCERIDEMIA.

Hurh E.; Gunawan R.; Collins J. W.; Burroughs E. G.; Wang Y.

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POPULATION PHARMACOKINETICS OF VOLANESORSEN, AN ANTISENSE OLIGONUCLEOTIDE TARGETING HUMAN APOLIPOPROTEIN C-III, IN HEALTHY SUBJECTS AND PATIENTS WITH FAMILIAL CHYLOMICRONEMIA SYNDROME OR HYPERTRIGLYCERIDEMIA.

机译：vlaneSorsen的人口药代动力学，靶向人载脂蛋白C-III的反义寡核苷酸，健康受试者和家族性乳瘤症综合征或高甘油苷血症的患者。

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来源
《Clinical Pharmacology and Therapeutics》 |2018年第1期|共1页
作者
Hurh E.; Gunawan R.; Collins J. W.; Burroughs E. G.; Wang Y.;
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作者单位

Akcea Therapeut Cambridge MA USA;

Ionis Pharmaceut Carlsbad CA USA;

PAREXEL Int Res Triangle Pk NC USA;

PAREXEL Int Res Triangle Pk NC USA;

Ionis Pharmaceut Carlsbad CA USA;

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正文语种 eng
中图分类药理学;
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1. POPULATION PHARMACOKINETICS OF VOLANESORSEN, AN ANTISENSE OLIGONUCLEOTIDE TARGETING HUMAN APOLIPOPROTEIN C-III, IN HEALTHY SUBJECTS AND PATIENTS WITH FAMILIAL CHYLOMICRONEMIA SYNDROME OR HYPERTRIGLYCERIDEMIA. [J] . Hurh E., Gunawan R., Collins J. W., Clinical Pharmacology and Therapeutics . 2018,第Suppla1期

机译：vlaneSorsen的人口药代动力学，靶向人载脂蛋白C-III的反义寡核苷酸，健康受试者和家族性乳瘤症综合征或高甘油苷血症的患者。
2. VOLANESORSEN Antisense oligonucleotide targeting ApoC-III Treatment of familial chylomicronemia syndrome Treatment of hypertriglyceridemia Treatment of lipodystrophy [J] . Pecin I., Nedic M., Reiner Z. Drugs of the Future . 2016,第7期

机译：VOLANESORSEN靶向ApoC-III的反义寡核苷酸治疗家族性乳糜微粒血症综合征高甘油三酸酯血症的治疗脂肪营养不良的治疗
3. POPULATION PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING FOR AN ANTISENSE OLIGONUCLEOTIDE (ISIS-FXIRx), TARGETING FACTOR XI, IN HEALTHY SUBJECTS. [J] . Yu R., Luu K., Bethune C., Clinical Pharmacology and Therapeutics . 2015,第S1期

机译：目标对象XI的健康人群中抗药性寡核苷酸（ISIS-FXIRx）的种群药动学/药动学（PK / PD）模型。
4. Computational Fluid Dynamic (CFD) in Thai patient with Obstructive Sleep Apnea Syndrome (OSAS) A case report: Comparative study between healthy and OSA subject [C] . Sarasaen Chompunuch, Hemtiwakorn Khaisang, Bhongmakapat Thongchai, The 5th Biomedical Engineering International Conference. . 2012

机译：泰国阻塞性睡眠呼吸暂停综合症（OSAS）患者的计算流体动力学（CFD）病例报告：健康人与OSA患者之间的比较研究
5. Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Healthy Subjects and Patients with Chronic Liver Disease [D] . NOMOTO, Maiko 2019

机译：阿法曲巴帕在健康受试者和慢性肝病患者中的药代动力学/药效学分析
6. A population pharmacokinetic meta‐analysis of custirsen an antisense oligonucleotide in oncology patients and healthy subjects [O] . Alena Y. Edwards, Anna Elgart, Colm Farrell, 2017

机译：肿瘤患者和健康受试者中的一种反义寡核苷酸库斯汀的人群药代动力学荟萃分析
7. Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes [O] . Andres Digenio, Richard L. Dunbar, Veronica J. Alexander, 2016

机译：通过VALANESOREN的反义介导的血浆载脂蛋白C-III降低改善了2型糖尿病的血脂血症和胰岛素敏感性

POPULATION PHARMACOKINETICS OF VOLANESORSEN, AN ANTISENSE OLIGONUCLEOTIDE TARGETING HUMAN APOLIPOPROTEIN C-III, IN HEALTHY SUBJECTS AND PATIENTS WITH FAMILIAL CHYLOMICRONEMIA SYNDROME OR HYPERTRIGLYCERIDEMIA.

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