Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

Peigne Sophie; Chhun Stephanie; Tod Michel; Rey Elisabeth; Rodrigues Christelle; Chiron Catherine; Pons Gerard; Jullien Vincent

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Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

机译：用甘油酚，丙普罗特和克罗巴唑组合治疗治疗Dravet综合征的儿科患者的人口药代动力学

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The aim of this study was to describe the pharmacokinetics of stiripentol in children with Dravet syndrome and to determine the concentrations of stiripentol achieved in this population for the usual 25 mg/kg twice-daily dose.

机译：本研究的目的是描述Dravet综合征儿童甲烷酮的药代动力学，并确定通常25mg / kg两次每日剂量的甲烷醇浓度的甲烷醇浓度。

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《Clinical pharmacokinetics》 |2018年第6期|共10页
作者
Peigne Sophie; Chhun Stephanie; Tod Michel; Rey Elisabeth; Rodrigues Christelle; Chiron Catherine; Pons Gerard; Jullien Vincent;
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作者单位

INSERM U1129 Paris France;

INSERM U1129 Paris France;

Univ Lyon 1 Fac Pharm Dept Physiol Pharmacol Toxicol Lyon France;

INSERM U1129 Paris France;

INSERM U1129 Paris France;

INSERM U1129 Paris France;

INSERM U1129 Paris France;

INSERM U1129 Paris France;

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正文语种 eng
中图分类药理学;
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1. Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy [J] . Peigne Sophie, Chhun Stephanie, Tod Michel, Clinical pharmacokinetics . 2018,第6期

机译：用甘油酚，丙普罗特和克罗巴唑组合治疗治疗Dravet综合征的儿科患者的人口药代动力学
2. Pharmacokinetics of Clobazam and N-Desmethylclobazam in Children with Dravet Syndrome Receiving Concomitant Stiripentol and Valproic Acid [J] . Jullien Vincent, Chhun Stephanie, Rey Elisabeth, Clinical pharmacokinetics . 2015,第5期

机译：丁苯喷醇和丙戊酸伴发德拉韦综合征的儿童中的氯巴沙姆和N-去甲基克洛嗪的药代动力学
3. Marked efficacy of combined three‐drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome [J] . Morimoto M., Shimakawa S., Hashimoto T., Journal of Clinical Pharmacy and Therapeutics . 2018,第4期

机译：将三种药物治疗（戊酸钠，吡酰胺和甘油替脂酚醇）在患者中标记为DRAVET综合征的疗效
4. Results of treatment of patients with stomach cancer advanced form treated by combination of lw level laser therapy (LLLT) and other methods (10-years experience) [C] . V.A.Mikhailov Conference on Laser Florence'99: A Window on the Laser Medicine World 28-31 October 1999 Florence, Italy . 1999

机译：低水平激光疗法（LLLT）和其他方法相结合治疗晚期胃癌患者的结果（10年经验）
5. Applications of Physiologically Based Pharmacokinetic Modelling to Prediction of the Likelihood of Metabolic Drug Interactions in Paediatric Population and Studying Disparities in Pharmacokinetics Between Children and Adults [D] . Salem, Farzaneh. 2014

机译：基于生理的药代动力学模型在小儿人群中代谢药物相互作用的可能性预测和研究儿童与成人之间药代动力学差异的应用
6. A phase I randomized open-label single-dose 3-period crossover study to evaluate the drug-drug interaction between ZX008 (fenfluramine HCl oral solution) and a regimen of stiripentol clobazam and valproate in healthy subjects [O] . Brooks Boyd, Steven Smith, Arnold Gammaitoni, -1

机译：I期随机开放标签单剂量3期交叉研究用于评估健康受试者中ZX008（芬氟拉明HCl口服溶液）与替比替多氯巴沙姆和丙戊酸盐的治疗方案之间的药物相互作用
7. A Case of Dravet Syndrome Who Developed Acute Reversible Encephalopathy That May Have Been Caused by Hyperamonnemia Due to Pharmacokinetic Interaction Between Valproate and Stiripentol [O] . Murat Mert ATMACA, Candan GÜRSES, Fidan MARUFOĞLU, 2012

机译：一例Dravet综合征发展为急性可逆性脑病的原因可能是丙戊酸盐与斯替戊喷醇之间的药代动力学相互作用引起的高氨血症
8. Clobazam-Treated Patients with Lennox Gastaut Syndrome Experienced Fewer Seizure-Related Injuries than Placebo Patients During Trail OV-1012. [R] . Isojarvi, J., Lee, D., Peng, G., 2016

机译：在过去OV-1012期间，患有Lennox Gastaut综合征的Clobazam治疗患者经历的癫痫发作相关损伤少于安慰剂患者。

Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy

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