Effectiveness of Delayed-release Dimethyl Fumarate on Clinical and Patient-reported Outcomes in Patients With Relapsing Multiple Sclerosis Switching From Glatiramer Acetate: RESPOND, a Prospective Observational Study

Kresa-Reahl Kiren; Repovic Pavle; Robertson Derrick; Okwuokenye Macaulay; Meltzer Leslie; Mendoza Jason P.

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Effectiveness of Delayed-release Dimethyl Fumarate on Clinical and Patient-reported Outcomes in Patients With Relapsing Multiple Sclerosis Switching From Glatiramer Acetate: RESPOND, a Prospective Observational Study

机译：促进释放二甲基富马酸乳酸型患者患者临床和患者报告结果的有效性，从Glativeramer醋酸酯复发多发性硬化切换：响应，前瞻性观察研究

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摘要

Purpose: The goal of this study was to evaluate clinical outcomes and patient-reported outcomes (PROs) over 12 months in patients with relapsing multiple sclerosis (RMS) who switched from glatiramer acetate (GA) to delayed-release dimethyl fumarate (DMF) 240 mg BID after suboptimal response to GA in real-world clinical practice.

机译：目的：本研究的目标是评估12个月内重复从Glatizamer醋酸酯（GA）转换为延迟释放二甲基富马酸酯（DMF）240的临床结果（RMS）的临床结果和患者报告在现实世界临床实践中对GA的次优应对次优响应后出价。

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来源
《Clinical therapeutics》 |2018年第12期|共11页
作者
Kresa-Reahl Kiren; Repovic Pavle; Robertson Derrick; Okwuokenye Macaulay; Meltzer Leslie; Mendoza Jason P.;
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作者单位

Providence Multiple Sclerosis Ctr Portland OR USA;

Swedish Neurosci Inst Multiple Sclerosis Ctr Seattle WA USA;

USF Multiple Sclerosis Ctr Tampa FL USA;

Biogen 225 Binney St Cambridge MA 02142 USA;

Biogen 225 Binney St Cambridge MA 02142 USA;

Biogen 225 Binney St Cambridge MA 02142 USA;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
annualized relapse rate; delayed-release dimethyl fumarate; glatiramer acetate; patient-reported outcomes; relapsing multiple sclerosis;

机译：年化复发率;延迟释放二甲基富马酸盐;Glatiramer醋酸盐;患者报告的结果;复发多发性硬化症;

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专利

1. Effectiveness of Delayed-release Dimethyl Fumarate on Clinical and Patient-reported Outcomes in Patients With Relapsing Multiple Sclerosis Switching From Glatiramer Acetate: RESPOND, a Prospective Observational Study (vol 40, pg 2077, 2018) [J] . Kresa-Reahl Kiren, Repovic Pavle, Robertson Derrick, Clinical therapeutics . 2019,第12期

机译：富马酸乳酸延迟释放二甲基患者患者临床和患者报告的结果的有效性，从Glatiramer醋酸酯复发多发性硬化切换：响应，前瞻性观察研究（Vol 40，PG 2077,2018）
2. Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing–remitting multiple sclerosis in a real-world clinical setting: PROTEC [J] . T Berger, B Brochet, L Brambilla, Multiple Sclerosis Journal ?C Experimental, Translational and Clinical . 2019,第4期

机译：在现实世界临床环境中复发延迟患者患者报告的患者报告结果和临床措施的有效性：PROTEC
3. THE COST-EFFECTIVENESS OF DELAYED-RELEASE DIMETHYL FUMARATE VERSUS GLATIRAMER ACETATE FOR THE TREATMENT OF RELAPSING REMITTING MULTIPLE SCLEROSIS IN THE CHILEAN NATIONAL HEALTH FUND (FONASA) [J] . Noda C., de Anda J. A., Anaya P., Value in health: the journal of the International Society for Pharmacoeconomics and Outcomes Research . 2016,第7期

机译：延缓释放富马酸二甲酯对乙酸格拉酯治疗智利国家卫生基金（FONASA）缓解多发性硬化症的成本效益
4. A machine learning pipeline for multiple sclerosis course detection from clinical scales and patient reported outcomes [C] . Fiorini Samuele, Verri Alessandro, Tacchino Andrea, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：用于从临床量表和患者报告的结果进行多发性硬化症课程检测的机器学习管道
5. The Impact of Peri-implant Soft Tissue Properties on Patient-reported and Clinically Assessed Outcomes: A Prospective Study. [D] . Bonino, Francesca. 2015

机译：植入物周围软组织特性对患者报告和临床评估结果的影响：一项前瞻性研究。
6. Effectiveness of delayed-release dimethyl fumarate onpatient-reported outcomes and clinical measures in patients withrelapsing–remitting multiple sclerosis in a real-world clinicalsetting: PROTEC [O] . T Berger, B Brochet, L Brambilla, 2019

机译：延缓释放富马酸二甲酯对患者报告的结局和临床措施现实世界中复发缓解型多发性硬化症设置：PROTEC
7. Corrigendum to “Effectiveness of Delayed-release Dimethyl Fumarate on Clinical and Patient-reported Outcomes in Patients With Relapsing Multiple Sclerosis Switching From Glatiramer Acetate: RESPOND, a Prospective Observational Study” Clinical Therapeutics 40 (12) (2018) 2077–2087 [O] . Kiren Kresa-Reahl, Pavle Repovic, Derrick Robertson, 2019

机译：“延迟释放二甲基富马酸二甲基患者患者临床和患者报告的患者的临床和患者报告结果的勘探性勘察：响应，一个前瞻性观察研究”临床治疗40（12）（2018）2077-2087

Effectiveness of Delayed-release Dimethyl Fumarate on Clinical and Patient-reported Outcomes in Patients With Relapsing Multiple Sclerosis Switching From Glatiramer Acetate: RESPOND, a Prospective Observational Study

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