Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin

Wang Xu; Beitler Jonathan J.; Huang Wen; Chen Guo; Qian Guoqing; Magliocca Kelly; Patel Mihir R.; Chen Amy Y.; Zhang Jun; Nannapaneni Sreenivas; Kim Sungjin; Chen Zhengjia; Deng Xingming; Saba Nabil F.; Chen Zhuo Georgia; Arbiser Jack L.; Shin Dong M.

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Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin

机译：通过Survivin的下调，HONOKIOL靶向头部和颈部的鳞状细胞癌

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Purpose: Previous studies revealed diverging results regarding the role of survivin in squamous cell carcinoma of the head and neck (SCCHN). This study aimed to evaluate the clinical significance of survivin expression in SCCHN; the function of survivin in DNA-damage repair following ionizing radiation therapy (RT) in SCCHN cells; and the potential of honokiol to enhance RT through downregulation of survivin.

机译：目的：之前的研究表明，关于Survivin在头部和颈部鳞状细胞癌中的作用的发散结果。本研究旨在评估Scchn中Survivin表达的临床意义; SCCHN细胞中电离辐射治疗后Survivin在DNA损伤修复中的功能; 并通过Survivin的下调来增强RT的潜力。

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来源
《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第4期|共12页
作者
Wang Xu; Beitler Jonathan J.; Huang Wen; Chen Guo; Qian Guoqing; Magliocca Kelly; Patel Mihir R.; Chen Amy Y.; Zhang Jun; Nannapaneni Sreenivas; Kim Sungjin; Chen Zhengjia; Deng Xingming; Saba Nabil F.; Chen Zhuo Georgia; Arbiser Jack L.; Shin Dong M.;
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作者单位

Emory Univ Sch Med Winship Canc Inst Dept Hematol &

Med Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Radiat Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Radiat Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Radiat Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Hematol &

Med Oncol Atlanta GA USA;

Emory Univ Sch Med Dept Pathol Winship Canc Inst Atlanta GA 30322 USA;

Emory Univ Sch Med Winship Canc Inst Dept Otolaryngol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Otolaryngol Atlanta GA USA;

Univ Iowa Holden Comprehens Canc Ctr Div Hematol Oncol &

Blood &

Marrow Transplantat Dept;

Emory Univ Sch Med Winship Canc Inst Dept Hematol &

Med Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Biostat &

Bioinformat Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Biostat &

Bioinformat Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Radiat Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Hematol &

Med Oncol Atlanta GA USA;

Emory Univ Sch Med Winship Canc Inst Dept Hematol &

Med Oncol Atlanta GA USA;

Emory Univ Sch Med Dept Dermatol Winship Canc Inst Atlanta GA 30322 USA;

Emory Univ Sch Med Winship Canc Inst Dept Hematol &

Med Oncol Atlanta GA USA;

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正文语种 eng
中图分类肿瘤学;
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1. Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin [J] . Wang Xu, Beitler Jonathan J., Huang Wen, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第4期

机译：通过Survivin的下调，HONOKIOL靶向头部和颈部的鳞状细胞癌
2. 3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226. [J] . Hehlgans S, Lange I, Eke I Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2009,第3期

机译：粘着斑激酶抑制剂TAE226对人类头颈部鳞状细胞癌细胞的3D细胞培养物进行放射增敏。
3. alpha integrin targeting for radiosensitization of three-dimensionally grown human head and neck squamous cell carcinoma cells [J] . Steglich Anne, Vehlow Anne, Eke Iris, Cancer letters . 2015,第2期

机译：α整联蛋白靶向用于三维生长的人头颈部鳞状细胞癌细胞的放射增敏
4. Adenylyl Cyclase-Associated Protein 1 in Metastasis of Squamous Cell Carcinoma of the Head and Neck and Non-Small Cell Lung Cancer [C] . G. V. Kakurina, E. S. Kolegova, O. V. Cheremisina, International Conference on Physics of Cancer . 2016

机译：腺苷酸环酶相关蛋白1在头部和颈部和非小细胞肺癌的鳞状细胞癌转移中
5. PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma. [D] . 野﨑, 結 2019

机译：PD-L1特异性辅助性T细胞表现出有效的抗肿瘤反应：针对头颈部鳞状细胞癌中PD-L1的癌症免疫疗法的新策略。
6. Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin [O] . Xu Wang, Jonathan J Beitler, Wen Huang, -1

机译：厚朴酚通过下调生存素使头颈部鳞状细胞癌致敏
7. The Small Molecule Inhibitor QLT0267 Radiosensitizes Squamous Cell Carcinoma Cells of the Head and Neck [O] . Eke, Iris, Leonhardt, Franziska, Storch, Katja, 2009

机译：小分子抑制剂QLT0267对头颈部鳞状细胞癌细胞放射增敏

Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin

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