NKG2D-Dependent Antitumor Effects of Chemotherapy and Radiotherapy against Glioblastoma

Weiss Tobias; Schneider Hannah; Silginer Manuela; Steinle Alexander; Pruschy Martin; Polic Bojan; Weller Michael; Roth Patrick

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NKG2D-Dependent Antitumor Effects of Chemotherapy and Radiotherapy against Glioblastoma

机译：化疗和放疗对胶质母细胞瘤的NKG2D依赖性抗肿瘤作用

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Purpose: NKG2D is a potent activating immune cell receptor, and glioma cells express the cognate ligands (NKG2DL). These ligands are inducible by cellular stress and temozolomide (TMZ) or irradiation (IR), the standard treatment of glioblastoma, could affect their expression. However, a role of NKG2DL for the efficacy of TMZ and IR has never been addressed.

机译：目的：NKG2D是一种有效的激活免疫细胞受体，胶质瘤细胞表达同源配体（NKG2DL）。这些配体通过细胞应激和替莫唑胺（TMZ）或辐照（IR），胶质母细胞瘤的标准治疗可能影响其表达。然而，NKG2DL对TMZ和IR效能的作用从未得到解决。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第4期|共14页
作者
Weiss Tobias; Schneider Hannah; Silginer Manuela; Steinle Alexander; Pruschy Martin; Polic Bojan; Weller Michael; Roth Patrick;
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作者单位

Univ Hosp Zurich Dept Neurol Frauenklin Str 26 CH-8091 Zurich Switzerland;

Univ Hosp Zurich Dept Neurol Frauenklin Str 26 CH-8091 Zurich Switzerland;

Univ Hosp Zurich Dept Neurol Frauenklin Str 26 CH-8091 Zurich Switzerland;

Goethe Univ Frankfurt Inst Mol Med Frankfurt Germany;

Univ Zurich Zurich Switzerland;

Univ Rijeka Fac Med Dept Histol &

Embryol Rijeka Croatia;

Univ Hosp Zurich Dept Neurol Frauenklin Str 26 CH-8091 Zurich Switzerland;

Univ Hosp Zurich Dept Neurol Frauenklin Str 26 CH-8091 Zurich Switzerland;

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正文语种 eng
中图分类肿瘤学;
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1. NKG2D-Dependent Antitumor Effects of Chemotherapy and Radiotherapy against Glioblastoma [J] . Weiss Tobias, Schneider Hannah, Silginer Manuela, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第4期

机译：化疗和放疗对胶质母细胞瘤的NKG2D依赖性抗肿瘤作用
2. THE NKG2D SYSTEM MEDIATES ANTI-TUMOR EFFECTS OF CHEMOTHERAPY AND RADIOTHERAPY AGAINST GLIOBLASTOMA [J] . Weiss T., Schneider H., Silginer M., Neuro-Oncology . 2016,第suppla4期

机译：NKG2D系统介导化学疗法和放射疗法对胶质母细胞瘤的抗肿瘤作用
3. A COX-2 inhibitor enhances the antitumor effects of chemotherapy and radiotherapy for esophageal squamous cell carcinoma [J] . Gulbostan Yusup, Yasunori Akutsu, Muradil Mutallip, International journal of oncology . 2014,第4期

机译：COX-2抑制剂增强食管鳞状细胞癌化学疗法和放射疗法的抗肿瘤作用
4. Low Grade Glioma Growth Modeling Considering Chemotherapy and Radiotherapy Effects from Magnetic Resonance Images [C] . Ahmed Elazab, Hongmin Bai, Xiaodong Zhang, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

机译：考虑磁共振图像的化疗和放射疗法效应低等级的胶质瘤生长建模
5. Re-evaluation of 5-fluorouracil Bolus injection as a radiosensitizer for chemoradiotherapy using glioblastoma multiforme cells. [D] . Valdes Diaz, Gilmer. 2013

机译：使用多形性胶质母细胞瘤细胞对5-氟尿嘧啶注射液作为放射增敏剂进行放化疗的重新评估。
6. Correction to: The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [O] . C. Festuccia, A. Mancini, A. Colapietro, 2018

机译：更正为：一流的烷基化脱乙酰基酶抑制剂分子锡莫司汀显示抗肿瘤作用并且在胶质母细胞瘤临床前模型中与放疗具有协同作用
7. Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma [O] . Caleb J. Yelton, Swapan K. Ray 2018

机译：组蛋白脱乙酰酶和选择性组蛋白脱乙酰酶抑制剂，用于抗肿瘤作用及胶质母细胞瘤中的抗肿瘤免疫力

NKG2D-Dependent Antitumor Effects of Chemotherapy and Radiotherapy against Glioblastoma

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