T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling

Josefsson Sarah E.; Huse Kanutte; Kolstad Arne; Beiske Klaus; Pende Daniela; Steen Chloe B.; Inderberg Else Marit; Lingjaerde Ole Christian; Ostenstad Bjorn; Smeland Erlend B.; Levy Ronald; Irish Jonathan M.; Myklebust June H.

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling

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T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling

机译：表达检查点受体TIGIT的T细胞富含滤泡淋巴瘤肿瘤，并通过可逆抑制T细胞受体信号传导的特征

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Purpose: T cells infiltrating follicular lymphoma (FL) tumors are considered dysfunctional, yet the optimal target for immune checkpoint blockade is unknown. Characterizing coinhibitory receptor expression patterns and signaling responses in FL T-cell subsets might reveal new therapeutic targets.

机译：目的：渗透卵泡淋巴瘤（FL）肿瘤的T细胞被认为是功能障碍，但免疫检查点封闭的最佳目标是未知的。表征卷曲的受体表达模式和F1细胞亚群中的信号响应可能揭示新的治疗目标。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第4期|共12页
作者
Josefsson Sarah E.; Huse Kanutte; Kolstad Arne; Beiske Klaus; Pende Daniela; Steen Chloe B.; Inderberg Else Marit; Lingjaerde Ole Christian; Ostenstad Bjorn; Smeland Erlend B.; Levy Ronald; Irish Jonathan M.; Myklebust June H.;
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作者单位

Univ Oslo Ctr Canc Biomed Oslo Norway;

Univ Oslo Ctr Canc Biomed Oslo Norway;

Oslo Univ Hosp Dept Oncol Div Canc Med Oslo Norway;

Oslo Univ Hosp Dept Pathol Oslo Norway;

Osped Policlin San Martino Immunol Lab Genoa Italy;

Univ Oslo Ctr Canc Biomed Oslo Norway;

Oslo Univ Hosp Dept Cellular Therapy Oslo Norway;

Univ Oslo Ctr Canc Biomed Oslo Norway;

Oslo Univ Hosp Dept Oncol Div Canc Med Oslo Norway;

Univ Oslo Ctr Canc Biomed Oslo Norway;

Stanford Sch Med Div Oncol Stanford CA USA;

Vanderbilt Univ Dept Cell &

Dev Biol 221 Kirkland Hall Nashville TN 37235 USA;

Univ Oslo Ctr Canc Biomed Oslo Norway;

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正文语种 eng
中图分类肿瘤学;
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1. T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling [J] . Josefsson Sarah E., Huse Kanutte, Kolstad Arne, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第4期

机译：表达检查点受体TIGIT的T细胞富含滤泡淋巴瘤肿瘤，并通过可逆抑制T细胞受体信号传导的特征
2. 369a??Chimeric Antigen Receptors Deficient in Lck Signaling Require 4-1BB Costimulation to Expand in Vivo, Resist Regulatory T-Cell Suppression, and Treat Solid Tumors in Immune-Intact Hosts [J] . Suryadevara Carter M., Desai Rupen, Farber Samuel Harrison, Clinical neurosurgery. . 2016,第CNasuppla1期

机译：369a ?? Lck信号不足的嵌合抗原受体需要4-1BB协同刺激，以体内扩增，抵抗调节性T细胞抑制并治疗免疫完整宿主中的实体瘤
3. CD52 expression in peripheral T-cell lymphomas determined by combined immunophenotyping using tumor cell specific T-cell receptor antibodies. [J] . Geissinger E, Bonzheim I, Roth S Leukemia and lymphoma . 2009,第6期

机译：通过使用肿瘤细胞特异性T细胞受体抗体的联合免疫表型测定外周T细胞淋巴瘤中的CD52表达。
4. Engineering and Arming of Soluble T-Cell Receptors for Targeting of Tumor Specific HLA Ligands [C] . Dominik Maurer Protein Engineering Summit. . 2018

机译：肿瘤特异性HLA配体靶向可溶性T细胞受体的工程与武装
5. Alterations in cell surface receptor expression and intracellular signaling in Schwann cells derived from NF1 tumors. [D] . Dang, Ian Duc. 2002

机译：源自NF1肿瘤的雪旺细胞中细胞表面受体表达和细胞内信号传导的变化。
6. T cells expressing checkpoint receptor TIGIT are enriched in follicular lymphoma tumors and characterized by reversible suppression of T-cell receptor signaling [O] . Sarah E. Josefsson, Kanutte Huse, Arne Kolstad, -1

机译：表达检查点受体TIGIT的T细胞富含滤泡性淋巴瘤肿瘤其特征是可逆性抑制T细胞受体信号传导
7. T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling [O] . Sarah E. Josefsson, Kanutte Huse, Arne Kolstad, 2017

机译：表达检查点受体TIGIT的T细胞富含滤泡淋巴瘤肿瘤，并通过可逆抑制T细胞受体信号传导的特征

T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling

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