Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma

摘要

Purpose: We sought a novel approach against glioblastomas (GBM) focused on targeting signaling molecules localized in the tumor extracellular matrix (ECM). We investigated fibulin-3, a glycoprotein that forms the ECM scaffold of GBMs and promotes tumor progression by driving Notch and NFkB signaling.