Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis

Bartolome Ruben A.; Aizpurua Carmen; Jaen Marta; Torres Sofia; Calvino Eva; Imbaud Juan I.; Ignacio Casal J.

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Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis

机译：针对Cadherin RGD的单克隆抗体表现出对黑色素瘤和结肠直肠癌转移的治疗活动

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Purpose: New targets are required for the control of advanced metastatic disease. We investigated the use of cadherin RGD motifs, which activate the alpha 2 beta 1integrin pathway, as targets for the development of therapeutic monoclonal antibodies (mAb).

机译：目的：控制晚期转移性疾病需要新的靶标。我们研究了使用钙粘蛋白RGD基序，其激活α2β1Integrin途径，作为治疗单克隆抗体（MAb）的发展的靶标。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第2期|共12页
作者
Bartolome Ruben A.; Aizpurua Carmen; Jaen Marta; Torres Sofia; Calvino Eva; Imbaud Juan I.; Ignacio Casal J.;
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作者单位

CSIC Ctr Invest Biol Dept Cellular &

Mol Med Madrid Spain;

Prot Alternat SL Madrid Spain;

CSIC Ctr Invest Biol Dept Cellular &

Mol Med Madrid Spain;

CSIC Ctr Invest Biol Dept Cellular &

Mol Med Madrid Spain;

CSIC Ctr Invest Biol Dept Cellular &

Mol Med Madrid Spain;

Prot Alternat SL Madrid Spain;

CSIC Ctr Invest Biol Dept Cellular &

Mol Med Madrid Spain;

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正文语种 eng
中图分类肿瘤学;
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1. Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis [J] . Bartolome Ruben A., Aizpurua Carmen, Jaen Marta, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第2期

机译：针对Cadherin RGD的单克隆抗体表现出对黑色素瘤和结肠直肠癌转移的治疗活动
2. VEGFR2-targeted antibody fused with IFNamut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity [J] . Pengzhao Shang, Rui Gao, Yijia Zhu, 药学学报：英文版 . 2021,第002期

机译：VEGFR2靶向抗体与IFNAMUT融合调节结直肠癌的肿瘤微环境，表现出效力的抗肿瘤和抗转移活性
3. VEGFR2-targeted antibody fused with IFNαmut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity [J] . Pengzhao Shang, Rui Gao, Yijia Zhu, 药学学报（英文版） . 2021,第002期

机译：与IFNα的VEGFR2靶向抗体调节结直肠癌的肿瘤微环境，并表现出有效的抗肿瘤和抗转移活性
4. A Mathematical Model for Assessing KRAS Mutation Effect on Monoclonal Antibody Treatment of Colorectal Cancer [C] . Sheema Sameen, Roberto Barbuti, Paolo Milazzo, International Conference on Software Engineering and Formal Methods . 2015

机译：评估克拉斯突变对直肠癌单克隆抗体治疗的数学模型
5. Cloning and expression of a biosimilar chimeric monoclonal antibody directed against the human epidermal growth factor receptor and its production in CHO cells for treatment of colo-rectal cancer. [D] . Motiwala, Hatim Maqbulhusen. 2012

机译：针对人表皮生长因子受体的生物仿制药嵌合单克隆抗体的克隆和表达及其在CHO细胞中的产生，用于治疗结肠直肠癌。
6. VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers [O] . Rubén A. Bartolomé, Sofía Torres, Soledad Isern de Val, 2017

机译：VE-钙黏着蛋白RGD基序促进转移并构成黑色素瘤和乳腺癌的潜在治疗靶标
7. VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers [O] . Bartolomé, Rubén Álvaro, Torres, Sofía, Isern de Val, Soledad, 2016

机译：VE-钙黏着蛋白RGD基序促进转移，并构成黑色素瘤和乳腺癌的潜在治疗靶标

Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis

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