Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

Au-Yeung George; Lang Franziska; Azar Walid J.; Mitchell Chris; Jarman Kate E.; Lackovic Kurt; Aziz Diar; Cullinane Carleen; Pearson Richard B.; Mileshkin Linda; Rischin Danny; Karst Alison M.; Drapkin Ronny; Etemadmoghadam Dariush; Bowtell David D. L.

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Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

机译：通过细胞周期蛋白依赖性激酶2和Akt抑制选择性靶向细胞周期蛋白E1-扩增的高级浆液癌

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Purpose: Cyclin E1 (CCNE1) amplification is associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Here, we explore approaches to target CCNE1-amplified cancers and potential strategies to overcome resistance to targeted agents.

机译：目的：细胞周期蛋白E1（CCNE1）扩增与初级治疗抵抗和高级浆液癌癌（HGSC）的差。在这里，我们探讨靶向CCNE1可扩增的癌症的方法以及克服对目标药剂的抗性的潜在策略。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2017年第7期|共13页
作者
Au-Yeung George; Lang Franziska; Azar Walid J.; Mitchell Chris; Jarman Kate E.; Lackovic Kurt; Aziz Diar; Cullinane Carleen; Pearson Richard B.; Mileshkin Linda; Rischin Danny; Karst Alison M.; Drapkin Ronny; Etemadmoghadam Dariush; Bowtell David D. L.;
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作者单位

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Walter &

Eliza Hall Inst Med Res Parkville Vic Australia;

Walter &

Eliza Hall Inst Med Res Parkville Vic Australia;

Univ Melbourne Dept Pathol Parkville Vic Australia;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Univ Melbourne Sir Peter MacCallum Dept Med Oncol Parkville Vic Australia;

Univ Melbourne Sir Peter MacCallum Dept Med Oncol Parkville Vic Australia;

Dana Farber Canc Inst Dept Med Oncol Boston MA 02115 USA;

Univ Penn Penn Ovarian Canc Res Ctr Perelman Sch Med Dept Obstet &

Gynecol Div Gynecol Oncol;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

Peter MacCallum Canc Inst Div Canc Res Melbourne Vic Australia;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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1. Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition [J] . Au-Yeung George, Lang Franziska, Azar Walid J., Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第7期

机译：通过细胞周期蛋白依赖性激酶2和Akt抑制选择性靶向细胞周期蛋白E1-扩增的高级浆液癌
2. Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel [J] . Liu Xianzhe, Gao Yan, Shen Jacson, Molecular cancer therapeutics . 2016,第7期

机译：细胞周期蛋白依赖性激酶11（CDK11）是卵巢癌细胞体外和体内生长所必需的，其抑制作用导致细胞凋亡，并使细胞对紫杉醇敏感。
3. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. [J] . Viglietto G, Motti ML, Bruni P, Nature medicine . 2002,第10期

机译：PKB / Akt介导的磷酸化在乳腺癌中的细胞质重定位和细胞周期蛋白依赖性激酶抑制剂p27（Kip1）的抑制作用。
4. Global proteomic analysis of ovarian high-grade serous carcinomas using SWATH-MS for targeted verification of proteome changes associated with genomic alterations [C] . Stefani N. Thomas, Jing Chen, Paul Aiyetan, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：卵巢高级浆液癌的全局蛋白质组学分析使用SWATH-MS进行靶向验证与基因组改变相关的蛋白质组变化
5. Epigenetic Targeting of Adipocytes Inhibits High-grade Serous Ovarian Cancer Cell Migration and Invasion [D] . Tang, Jessica. 2018

机译：表观遗传靶向的脂肪细胞抑制高级浆液性卵巢癌细胞的迁移和侵袭
6. Selective targeting of Cyclin E1 amplified high grade serous ovarian cancer by cyclin-dependent kinase 2 and AKT inhibition [O] . George Au-Yeung, Franziska Lang, Walid J. Azar, -1

机译：通过细胞周期蛋白依赖性激酶2和AKT抑制选择性靶向Cyclin E1扩增高级别浆液性卵巢癌
7. Targeting galectin-3 with a high-affinity antibody for inhibition of high-grade serous ovarian cancer and other MUC16/CA-125-expressing malignancies [O] . Marina Stasenko, Evan Smith, Oladapo Yeku, 2021

机译：用高亲和力抗体靶向Galectin-3，用于抑制高级浆液卵巢癌和其他MUC16 / CA-125表达的恶性肿瘤

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

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