Imaging Tumor Acidity: pH-Low Insertion Peptide Probe for Optoacoustic Tomography

摘要

Optoacoustic tomography has been used for the detection of pancreatic ductal adenocarcinoma targeted by pH-low insertion peptide (pHLIP) conjugated to near-infrared fluorescent dye. It was proved that tumor targeting is pH dependent. The approach could have major implication for detection and monitoring of pancreatic and other cancers. (C) 2015 AACR.