“All Our Wisdom is Stored in the Trees” - Degrading BCR-ABL with Berberis Vulgaris

摘要

Treating BCR-ABL–positive chronic myeloid leukemia remains impeded by the development of clinical resistance to imatinib. It has been demonstrated that berberine, a plant alkaloid, has activity against imatinib-resistant BCR-ABL mutants by inducing autophagic degradation of BCR-ABL, thereby preventing the acquisition of drug-resistant mutations.