Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas

Thompson John A.; Motzer Robert J.; Molina Ana M.; Choueiri Toni K.; Heath Elisabeth I.; Redman Bruce G.; Sangha Randeep S.; Ernst D. Scott; Pili Roberto; Kim Stella K.; Reyno Leonard; Wiseman Aya; Trave Fabio; Anand Banmeet; Morrison Karen; Donate Fernando; Kollmannsberger Christian K.

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Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas

机译：抗ENPP3抗体 - 药物缀合物中的抗ENPP3抗体 - 药物癌中的阶段

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Purpose: To determine the safety, pharmacokinetics, and recommended phase II dose of an antibody-drug conjugate (ADC) targeting ectonucleotide phosphodiesterases-pyrophosphatase 3 (ENPP3) conjugated to monomethyl auristatin F (MMAF) in subjects with advanced metastatic renal cell carcinoma (mRCC).

机译：目的：确定靶向药物缀合物（ADC）的安全性，药代动力学和推荐的抗体 - 药物缀合物（ADC）靶向与先进的转移性肾细胞癌（MRCC ）。

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来源
《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第18期|共8页
作者
Thompson John A.; Motzer Robert J.; Molina Ana M.; Choueiri Toni K.; Heath Elisabeth I.; Redman Bruce G.; Sangha Randeep S.; Ernst D. Scott; Pili Roberto; Kim Stella K.; Reyno Leonard; Wiseman Aya; Trave Fabio; Anand Banmeet; Morrison Karen; Donate Fernando; Kollmannsberger Christian K.;
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作者单位

Univ Washington Div Med Oncol Seattle WA 98195 USA;

Mem Sloan Kettering Canc Ctr Dept Med 1275 York Ave New York NY 10021 USA;

Weill Cornell Med Coll Dept Med Div Hematol &

Med Oncol New York NY USA;

Harvard Med Sch Dana Farber Canc Inst Boston MA USA;

Karmanos Canc Ctr Div Hematol Oncol Detroit MI USA;

Univ Michigan Comprehens Canc Ctr Internal Med Ann Arbor MI 48109 USA;

Cross Canc Inst Edmonton AB Canada;

London Hlth Sci Ctr London ON Canada;

Indiana Univ Dept Oncol Bloomington IN USA;

Univ Texas Houston McGovern Med Sch Dept Opthalmol &

Visual Sci Houston TX USA;

Agensys Inc Dept Translat Res Santa Monica CA USA;

Agensys Inc Dept Translat Res Santa Monica CA USA;

Astellas Pharma Northbrook IL USA;

Astellas Pharma Northbrook IL USA;

Agensys Inc Dept Translat Res Santa Monica CA USA;

Agensys Inc Dept Translat Res Santa Monica CA USA;

Vancouver Ctr BC Canc Vancouver BC Canada;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
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专利

1. Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas [J] . Thompson John A., Motzer Robert J., Molina Ana M., Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第18期

机译：抗ENPP3抗体 - 药物缀合物中的抗ENPP3抗体 - 药物癌中的阶段
2. Targeting B-cell maturation antigen with GSK2857916 antibody-drug conjugate in relapsed or refractory multiple myeloma (BMA117159): a dose escalation and expansion phase 1 trial [J] . Trudel Suzanne, Lendvai Nikoletta, Popat Rakesh, The lancet oncology . 2018,第12期

机译：用GSK2857916抗体 - 药物缀合物靶向B细胞成熟抗原，在复发或难以多发性骨髓瘤（BMA117159）：剂量升级和膨胀阶段1试验
3. Phase I/II Trial of Labetuzumab Govitecan (Anti-CEACAM5/SN-38 Antibody-Drug Conjugate) in Patients With Refractory or Relapsing Metastatic Colorectal Cancer [J] . Dotan Efrat, Cohen Steven J., Starodub Alexander N., Journal of Clinical Oncology . 2017,第29期

机译：耐火或复发转移性结直肠癌患者的Labetuzuamab Govitecan（抗CeAcam5 / Sn-38抗体 - 药物缀合物）的I / II试验
4. Designing Phase III Trials in Metastatic Renal Cell Carcinoma: What Are the New Standards? [C] . Ana M. Molina Genitourinary Cancers Symposium . 2012

机译：在转移性肾细胞癌中设计III期试验：新标准是什么？
5. Investigating the Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates, T Cells and Bispecific Antibodies [D] . Khot, Antari . 2020

机译：调查抗体 - 药物缀合物，T细胞和双特异性抗体的药代动力学和药效学
6. PHASE 1 TRIALS OF ANTI-ENPP3 ANTIBODY DRUG CONJUGATES IN ADVANCED REFRACTORY RENAL CELL CARCINOMAS [O] . John A. Thompson, Robert J. Motzer, Ana M. Molina, -1

机译：抗ENPP3抗体药物在高级难治性肾细胞癌中的第一阶段试验。
7. Phase I Trials of Anti-ENPP3 Antibody–Drug Conjugates in Advanced Refractory Renal Cell Carcinomas [O] . John A. Thompson, Robert J. Motzer, Ana M. Molina, 2018

机译：抗ENPP3抗体 - 药物缀合物中的抗ENPP3抗体 - 药物癌中的阶段

Phase I Trials of Anti-ENPP3 Antibody-Drug Conjugates in Advanced Refractory Renal Cell Carcinomas

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