T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

Obradovic Aleksandar Z.; Dallos Matthew C.; Zahurak Marianna L.; Partin Alan W.; Schaeffer Edward M.; Ross Ashley E.; Allaf Mohamad E.; Nirschl Thomas R.; Liu David; Chapman Carolyn G.; ONeal Tanya; Cao Haiyi; Durham Jennifer N.; Guner Gunes; Baena-Del Valle Javier A.; Ertunc Onur; De Marzo Angelo M.; Antonarakis Emmanuel S.; Drake Charles G.

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

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T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

机译：T细胞浸润和适应性Treg抗性，响应于雄激素剥夺或在局部前列腺癌中的疫灭

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Purpose: Previous studies suggest that androgen deprivation therapy (ADT) promotes antitumor immunity in prostate cancer. Whether a vaccine-based approach can augment this effect remains unknown.

机译：目的：以前的研究表明雄激素剥夺治疗（ADT）促进前列腺癌中的抗肿瘤免疫力。无论是疫苗的方法是否可以增强这种效果仍然未知。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2020年第13期|共11页
作者
Obradovic Aleksandar Z.; Dallos Matthew C.; Zahurak Marianna L.; Partin Alan W.; Schaeffer Edward M.; Ross Ashley E.; Allaf Mohamad E.; Nirschl Thomas R.; Liu David; Chapman Carolyn G.; ONeal Tanya; Cao Haiyi; Durham Jennifer N.; Guner Gunes; Baena-Del Valle Javier A.; Ertunc Onur; De Marzo Angelo M.; Antonarakis Emmanuel S.; Drake Charles G.;
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作者单位

Columbia Univ Columbia Ctr Translat Immunol Irving Med Ctr New York NY USA;

Columbia Univ Med Ctr Herbert Irving Comprehens Canc Div Hematol &

Oncol New York NY USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol &

Biostat Baltimore MD USA;

Johns Hopkins Univ Brady Urol Inst Dept Urol Baltimore MD USA;

Northwestern Univ Feinberg Sch Med Dept Urol Chicago IL 60611 USA;

Texas Urol Specialists Dallas TX USA;

Johns Hopkins Univ Brady Urol Inst Dept Urol Baltimore MD USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol Baltimore MD USA;

Dana Farber Canc Inst Boston MA 02115 USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol Baltimore MD USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol Baltimore MD USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol Baltimore MD USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol Baltimore MD USA;

Johns Hopkins Univ Sch Med Dept Pathol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Pathol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Pathol Baltimore MD 21205 USA;

Johns Hopkins Univ Sch Med Dept Pathol Baltimore MD 21205 USA;

Johns Hopkins Sidney Kimmel Comprehens Canc Ctr Dept Oncol Baltimore MD USA;

Columbia Univ Columbia Ctr Translat Immunol Irving Med Ctr New York NY USA;

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正文语种 eng
中图分类肿瘤学;
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专利

1. T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer [J] . Obradovic Aleksandar Z., Dallos Matthew C., Zahurak Marianna L., Clinical cancer research: an official journal of the American Association for Cancer Research . 2020,第13期

机译：T细胞浸润和适应性Treg抗性，响应于雄激素剥夺或在局部前列腺癌中的疫灭
2. Patient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer [J] . Karen E. Hoffman, David F. Penson, Zhiguo Zhao, JAMA: the Journal of the American Medical Association . 2020,第2期

机译：患者报告的结果通过5年的活跃监测，手术，近距放疗或外部光束辐射，或没有雄激素剥夺治疗局部前列腺癌
3. Phase 2 Randomized Study of Radiation Therapy and 3-Year Androgen Deprivation With or Without Concurrent Weekly Docetaxel in High-Risk Localized Prostate Cancer Patients [J] . Carles Joan, Gallardo Enrique, Domenech Montserrat, International Journal of Radiation Oncology, Biology, Physics . 2019,第2期

机译：第2期随机研究放射治疗和3年雄激素剥夺，在高危局部前列腺癌患者中没有同时的每周多西紫杉醇
4. Serum levels of sex hormones before and after androgen deprivation therapy in Japanese prostate cancer patients [C] . A. Komiya, K. Ichimatsu, A. Morii, International Congress of Andrology . 2009

机译：日本前列腺癌患者中雄激素剥夺治疗前后的性激素血清水平
5. T-Cell Checkpoints, and the PD-1/L1 Pathway in Particular, are a Mode of Resistance to DNA Vaccination and Rational Combination Therapies Improve Vaccine Efficacy for the Treatment of Prostate Cancer. [D] . Rekoske, Brian. 2017

机译：T细胞检查点以及PD-1 / L1途径尤其是对DNA疫苗产生抗药性的一种方式，合理的联合疗法可提高疫苗治疗前列腺癌的功效。
6. The prognostic value of expression of HIF1α EGFR and VEGF-A in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy [O] . Damien C Weber, Jean-Christophe Tille, Christophe Combescure, 2012

机译：HIF1αEGFR和VEGF-A在局部前列腺癌中的表达对接受或不接受雄激素剥夺治疗的中高危患者的预后价值
7. Pretreatment frequency of circulating IL-17(+)CD4(+) T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients [O] . Derhovanessian E, Adams V, Haehnel K, 2009

机译：循环IL-17（+）CD4（+）T细胞（而非Treg）的预处理频率与前列腺癌患者对全细胞疫苗接种的临床反应相关

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer

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