Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

Cazzamalli Samuele; Ziffels Barbara; Widmayer Fontaine; Murer Patrizia; Pellegrini Giovanni; Pretto Francesca; Wulhfard Sarah; Neri Dario

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

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Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

机译：增强非内化小分子药物缀合物的治疗活性，靶向碳酸酐酶IX与靶向白细胞介素-2组合

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Purpose: Antibody-drug conjugates and small-molecule-drug conjugates have been proposed as alternatives to conventional anticancer cytotoxic agents, with the potential to deliver bioactive payloads to the site of disease, helping spare normal tissues.

机译：目的：已经提出了抗体 - 药物缀合物和小分子 - 药物缀合物作为常规抗癌细胞毒性剂的替代品，具有将生物活性有效载荷递送到疾病部位，帮助备用正常组织。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第15期|共12页
作者
Cazzamalli Samuele; Ziffels Barbara; Widmayer Fontaine; Murer Patrizia; Pellegrini Giovanni; Pretto Francesca; Wulhfard Sarah; Neri Dario;
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Swiss Fed Inst Technol Swiss Fed Inst Technol Dept Appl Biosci Zurich Switzerland;

Swiss Fed Inst Technol Swiss Fed Inst Technol Dept Appl Biosci Zurich Switzerland;

Swiss Fed Inst Technol Swiss Fed Inst Technol Dept Appl Biosci Zurich Switzerland;

Swiss Fed Inst Technol Swiss Fed Inst Technol Dept Appl Biosci Zurich Switzerland;

Univ Zurich Inst Vet Pathol Lab Anim Model Pathol Zurich Switzerland;

Philochem AG Libernstr 3 Otelfingen Switzerland;

Philochem AG Libernstr 3 Otelfingen Switzerland;

Swiss Fed Inst Technol Swiss Fed Inst Technol Dept Appl Biosci Zurich Switzerland;

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正文语种 eng
中图分类肿瘤学;
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1. Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2 [J] . Cazzamalli Samuele, Ziffels Barbara, Widmayer Fontaine, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第15期

机译：增强非内化小分子药物缀合物的治疗活性，靶向碳酸酐酶IX与靶向白细胞介素-2组合
2. Carbonic anhydrase inhibitors: Gd(m) complexes of DOTA- and TETA-sulfonamide conjugates targeting the tumor associated carbonic anhydrase isozymes IX and XII [J] . Marouan Rami, Jean-Louis Montero, Ludwig Dubois New Journal of Chemistry . 2010,第10期

机译：碳酸酐酶抑制剂：针对肿瘤相关碳酸酐酶同工酶IX和XII的DOTA-和TETA-磺酰胺结合物的Gd（m）复合物
3. [(Cp-R)M(CO)3] (M = Re or ~(99m)Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX [J] . Daniel Can, Bernhard Spingler, Paul Schmutz Angewandte Chemie . 2012,第14期

机译：[（Cp-R）M（CO）3]（M = Re或〜（99m）Tc）芳基磺酰胺，芳基磺酰胺和芳基氨基磺酸盐偶联物，用于选择性靶向人碳酸酐酶IX
4. QSAR AND DOCKING STUDIES ON TRIAZOLE BENZENE SULFONAMIDES WITH HUMAN CARBONIC ANHYDRASE IX INHIBITORY ACTIVITY [C] . Gopinath P., Kathiravan M.K. Conference on Drug Design and Discovery Technologies . 2020

机译：用人碳酸酐酶IX抑制活性对三唑苯磺胺酰胺的QSAR和对接研究
5. Combination therapeutic strategies targeting growth and metabolic pathways in prostate cancer. [D] . Canatsey, Ryan Douglas. 2016

机译：针对前列腺癌的生长和代谢途径的联合治疗策略。
6. Enhanced Therapeutic Activity of Non-Internalizing Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination With Targeted Interleukin-2 [O] . Samuele Cazzamalli, Barbara Ziffels, Fontaine Widmayer, -1

机译：非内在化小分子药物与靶向白介素-2结合的靶向碳酸酐酶IX的增强的治疗活性。
7. Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: A new concept of dual targeting drugs [O] . Dubois, Ludwig, Peeters, Sarah G. J. A., van Kuijk, Simon J. A., 2013

机译：基于硝基咪唑的磺酰胺靶向碳酸酐酶IX增强了肿瘤放射的治疗效果：双重靶向药物的新概念

Enhanced Therapeutic Activity of Non-Internalizing Small-Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination with Targeted Interleukin-2

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