A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer

Zhang Qianwen; Zhang Yan; Chen Yaqing; Qian Jianchang; Zhang Xuesai; Yu Ker

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A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer

机译：一种新型MTORC1 / 2抑制剂（MTI-31）抑制肿瘤生长，上皮 - 间充质转变，转移，并在肺癌的临床前模型中提高抗肿瘤免疫力

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Purpose: We aimed to investigate efficacy and mechanism of MTI-31 (LXI-15029), a novel mTORC1/mTORC2 inhibitor currently in human trial (NCT03125746), in non-small cell lung cancer (NSCLC) models of multiple driver mutations and tyrosine kinase inhibitor (TKI)-resistance.

机译：目的：我们旨在研究MTI-31（LXI-15029），新型MTORC1 / MTORC2抑制剂，目前在人类试验中的新型MTORC1 / MTORC2抑制剂，在多个驾驶员突变和酪氨酸的非小细胞肺癌（NSCLC）模型中进行人体试验（NCT03125746）的疗效和机制激酶抑制剂（TKI）-Resistance。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2019年第12期|共13页
作者
Zhang Qianwen; Zhang Yan; Chen Yaqing; Qian Jianchang; Zhang Xuesai; Yu Ker;
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Fudan Univ Sch Pharm Dept Pharmacol Shanghai Peoples R China;

Fudan Univ Sch Pharm Dept Pharmacol Shanghai Peoples R China;

Fudan Univ Sch Pharm Dept Pharmacol Shanghai Peoples R China;

Fudan Univ Sch Pharm Dept Pharmacol Shanghai Peoples R China;

Fudan Univ Sch Pharm Dept Pharmacol Shanghai Peoples R China;

Fudan Univ Sch Pharm Dept Pharmacol Shanghai Peoples R China;

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正文语种 eng
中图分类肿瘤学;
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1. A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer [J] . Zhang Qianwen, Zhang Yan, Chen Yaqing, Clinical cancer research: an official journal of the American Association for Cancer Research . 2019,第12期

机译：一种新型MTORC1 / 2抑制剂（MTI-31）抑制肿瘤生长，上皮 - 间充质转变，转移，并在肺癌的临床前模型中提高抗肿瘤免疫力
2. Combination of proteasome and HDAC inhibitor enhances HPV16 E7-specific CD8Superscript+/Superscript T cell immune response and antitumor effects in a preclinical cervical cancer model [J] . Zhuomin Huang, Shiwen Peng, Jayne Knoff, Journal of biomedical science. . 2015,第1期

机译：蛋白酶体和HDAC抑制剂的组合可增强HPV16 E7特异性CD8 + T细胞的免疫应答和抗癌作用
3. Combination of proteasome and HDAC inhibitor enhances HPV16 E7-specific CD8+ T cell immune response and antitumor effects in a preclinical cervical cancer model [J] . Zhuomin Huang, Shiwen Peng, Jayne Knoff, Journal of biomedical science. . 2015,第1期

机译：蛋白酶体和HDAC抑制剂的组合可增强临床前宫颈癌模型中HPV16 E7特异性CD8 + T细胞的免疫应答和抗肿瘤作用
4. Novel Therapeutics for Inhibiting Tumor Epithelial-Mesenchymal Transition (EMT), a Key Driver of Metastasis and a Mechanism of Drug-Resistance [C] . Sergej M. Kiprijanov, Gro Gausdal, Tone Sal, PEGS . 2014

机译：抑制肿瘤上皮 - 间充质转换（EMT），转移的关键驱动器和抗药性机制的新型治疗剂
5. Mirna-143/506 Induces Cell Cycle Arrest and Inhibits Tumor Growth Using a Novel Nanocarrier in Lung Cancer [D] . Hossian, A. K. M. Nawshad. 2020

机译：miRNA-143/506诱导细胞周期停滞并使用肺癌中的新纳米载体抑制肿瘤生长
6. Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) [O] . Qingnan Zhao, Xiajing Gu, Chun Zhang, 2015

机译：在非小细胞肺癌（NSCLC）中阻断M2毒蕈碱受体信号传导可抑制肿瘤生长并逆转上皮-间质转化（EMT）
7. A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial–Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer [O] . Qianwen Zhang, Yan Zhang, Yaqing Chen, 2019

机译：一种新型MTORC1 / 2抑制剂（MTI-31）抑制肿瘤生长，上皮 - 间充质转变，转移，并在肺癌的临床前模型中提高抗肿瘤免疫力

A Novel mTORC1/2 Inhibitor (MTI-31) Inhibits Tumor Growth, Epithelial-Mesenchymal Transition, Metastases, and Improves Antitumor Immunity in Preclinical Models of Lung Cancer

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