Evaluation of TERT promoter mutations in urinary cell-free DNA and sediment DNA for detection of bladder cancer

摘要

Background: Cell-free DNA (cfDNA) is proposed to be a valuable source of biomarkers in liquid biopsies for various diseases as it is supposed to partially originate from tumor cells. However, data about the diagnostic implications of cfDNA in urine for the detection of bladder cancer (BCa) is sparse.