Treatment of chronic hepatitis C in children with pegylated interferon and ribavirin : the impact of dose

Tufano Maria; Cicalese Maria Pia; Spagnuolo Maria Immacolata; Terlizzi Vito; Iorio Raffaele

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Treatment of chronic hepatitis C in children with pegylated interferon and ribavirin : the impact of dose

机译：聚乙二醇干扰素联合利巴韦林治疗小儿慢性丙型肝炎：剂量的影响

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Introduction : In the last years children with chronic hepatitis C (CHC) have been treated with Pegylated Interferon a (PEG-IFN alpha) and ribavirin (RBV). Treatment can cause several side effects that require reduction or interruption of therapy. The relationship between dose of PEG-IFN alpha and response to therapy has not been clearly evaluated. Aim of this study was to evaluate the impact of the dose of PEG-IFN alpha 2b and RBV on the efficacy of therapy.

机译：简介：近年来，患有慢性丙型肝炎（CHC）的儿童接受了聚乙二醇化干扰素a（PEG-IFNα）和利巴韦林（RBV）的治疗。治疗可能会导致多种副作用，需要减少或中断治疗。尚未明确评估PEG-IFNα剂量与治疗反应之间的关系。这项研究的目的是评估PEG-IFNα2b和RBV剂量对治疗效果的影响。

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《Acta gastro-enterologica Belgica》 |2015年第1期|共4页
作者
Tufano Maria; Cicalese Maria Pia; Spagnuolo Maria Immacolata; Terlizzi Vito; Iorio Raffaele;
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正文语种 fre
中图分类消化系及腹部疾病;
关键词
hepatitis C virus; Pegylated Interferon alpha; children;

机译：丙型肝炎病毒;聚乙二醇干扰素α;儿童;

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1. Treatment of chronic hepatitis C in children with pegylated interferon and ribavirin : the impact of dose [J] . Tufano Maria, Cicalese Maria Pia, Spagnuolo Maria Immacolata, Acta gastro-enterologica Belgica . 2015,第1期

机译：聚乙二醇干扰素联合利巴韦林治疗小儿慢性丙型肝炎：剂量的影响
2. Association between the treatment length and cumulative dose of pegylated interferon alpha-2b plus ribavirin and their effectiveness as a combination treatment for Japanese chronic hepatitis C patients: project of the Kyushu University Liver Disease Study Group. [J] . Furusyo N, Kajiwara E, Takahashi K, Journal of gastroenterology and hepatology . 2008,第7aPta1期

机译：聚乙二醇化干扰素α-2b加利巴韦林的治疗时间和累积剂量之间的关联及其作为日本慢性丙型肝炎患者联合治疗的有效性：九州大学肝病研究小组的项目。
3. Factors affecting efficacy in patients with genotype 2 chronic hepatitis C treated by pegylated interferon alpha-2b and ribavirin: reducing drug doses has no impact on rapid and sustained virological responses. [J] . Inoue Y, Hiramatsu N, Oze T, Journal of viral hepatitis. . 2010,第5期

机译：影响聚乙二醇干扰素α-2b和利巴韦林治疗的基因型2型慢性丙型肝炎患者疗效的因素：减少药物剂量不会对快速和持续的病毒学应答产生影响。
4. Studies of Therapy with Thymosin α 1 in Combination with Pegylated Interferon α2a and Ribavirin in Nonresponder Patients with Chronic Hepatitis C [C] . ROBERTO CAMERINI, ALESSIA CIANCIO, ALFONSO DE ROSA, International Symposiumn on Thymosins in Health and Disease; 20070321-24; Washington,DC(US) . 2007

机译：胸腺素α1联合聚乙二醇化干扰素α2a和利巴韦林治疗慢性丙型肝炎无反应者的研究
5. The meaning of adherence among veterans receiving pegylated interferon and ribavirin antiviral treatment for chronic hepatitis C. [D] . Phillips, Frances Hinshaw. 2011

机译：接受聚乙二醇干扰素和利巴韦林抗病毒治疗的慢性丙型肝炎退伍军人依从性的含义。
6. The impact of pegylated interferon and ribavirin combination treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients [O] . Hee Jae Jung, Young Seok Kim, Sang Gyune Kim, 2014

机译：聚乙二醇干扰素联合利巴韦林对慢性丙型肝炎患者脂质代谢和胰岛素抵抗的影响
7. Alfapeguinterferon-2a e ribavirina versus alfapeguinterferon-2b e ribavirina: avaliação custo-efetividade e do impacto orçamentário do tratamento do genótipo 1 da hepatite C crônica Alfa-pegylated interferons (2a and 2b) and ribavirin for treatment chronic hepatitis C, genotype 1: a cost-effectiveness analysis [O] . Gabriela Bittencourt Gonzalez Mosegui, Cid Manso de Mello Vianna, Marcus Paulo da Silva Rodrigues, 2011

机译：alfapeguinterferon-2a和利巴韦林与alfapeguinterferon-2b和利巴韦林：慢性丙型肝炎基因型1治疗的成本效益和预算影响评估α-聚乙二醇化干扰素（2a和2b）和利巴韦林治疗慢性丙型肝炎，基因型1：a成本效益分析

Treatment of chronic hepatitis C in children with pegylated interferon and ribavirin : the impact of dose

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