Acidic environment activates inflammatory programs in fibroblasts via a cAMP-MAPK pathway

摘要

The tissue micromilieu in disorders (inflammation, ischemia, tumor) often shows pronounced metabolic acidosis that may alter signaling and transcriptional activity in resident cells which can be of special importance for omnipresent fibroblasts. In the present study we investigated the impact of metabolic acidosis on rat fibroblasts with special emphasis on their role in inflammation by regulation of TNF-alpha, MCP-1, COX-2 and iNOS expression and the signaling pathways involved.