Molekularbiologische Methoden zur HLA-Typisierung

摘要

The success of allogeneic stem cell transplantation depends upon the degree of human leukocyte antigen (HLA) compatibility between the donor and patient since T-cell responses to foreign HLA molecules can result in aggressive immune responses. The human HLA locus on chromosome 6 is highly polymorphic within the population. Due to the large number of allels, the exact determination of the individual HLA polymorphisms (HLA typing) is a technically challenging task requiring different molecular biological procedures.