Direct Oxidative Amidation between N,N-dimethylanilines and Anhydrides Using Metal-Organic Framework [Cu-2(EDB)(2)(BPY)] as an Efficient Heterogeneous Catalyst

摘要

A crystalline porous metal-organic framework [Cu-2(EDB)(2)(BPY)] was synthesized and used as a heterogeneous catalyst for the direct oxidative amidation between N, N-dimethylanilines and anhydrides to form tertiary amides as the principal products. The [Cu-2(EDB)(2)(BPY)] exhibited similar activity as compared to that of [Cu-2(BDC)(2)(BPY)], [Cu-2(BDC)(2)(DABCO)], MOF-143, and other common homogeneous salt catalysts. The optimal reaction conditions employed were [Cu-2(EDB)(2)(BPY)] (10% mol), TBHP (2 equiv), pyridine (1 equiv) in CH3CN at 80 degrees C over 2 h. The Cu-2(EDB)(2)(BPY) could be separated from the reaction mixture by filtration, and could be recovered and reused several times without a significant degradation in catalytic activity and selectivity. Furthermore, generality of the optimal conditions was confirmed by employing various N, N-dimethylaniline and anhydride derivatives.