NMR spectroscopy guides PK enhancement of cyclic peptides

摘要

Researchers from the Institute of Molecular Bioscience, University of Queensland, in collaboration with Pfizer USA, have used a novel approach to make orally bioavailable analogues of a cyclic heptapeptide natural product derived from a nudibranch (Nielsen D.S., Hoang H.N., Lohman RJ., HillT.A., Lucke A.J., Craik D.J., Edmonds D.J., Griffith D.A., Rotter C.J., Ruggeri R.B., Price D.A., Liras S., Fairlie D.P. Angew. Chem. Int. Ed. 2014, 45, 12059-63).