Photochemical Formation of Cyclobutane Pyrimidine Dimers in DNA through Electron Transfer from a Flanking Base

Lee Wook; Matsika Spiridoula

摘要

Abstract >Electron transfer (ET) to a pyrimidine base from external moieties is a common step involved in the quenching or repair of the cyclobutane pyrimidine dimer (CPD). In contrast, we present a pathway that is initiated by an ET from a flanking guanine base to a pyrimidine base, leading to the formation of a CPD. We studied a T5mCG sequence with a methylated cytosine and our results demonstrate that the pathway involves the formation of an exciplex and intersystem crossings. This pathway also provides an explanation for why the mutational hot spots are correlated with the methylated CpG sequences, which has been a significant issue in cancer research. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >电子转移到外部部分的嘧啶基础是涉及的常用步骤环丁烷嘧啶二聚体（CPD）的淬火或修复。相反，我们提出了一种由侧翼鸟嘌呤碱引发的途径，该途径向嘧啶基碱引发，导致CPD的形成。我们研究了具有甲基化胞嘧啶的T5MCG序列，我们的结果表明该途径涉及形成Exciplex和Intersysystem交叉口。该途径还提供了为什么突变热点与甲基化CpG序列相关的解释，这在癌症研究中是一个重要问题。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16300/'>《Chemphyschem: A European journal of chemical physics and physical chemistry 》</a> <b style="margin: 0 2px;">|</b><span>2018年第13期</span><b style="margin: 0 2px;">|</b> <span>共4页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lee Wook&option=202" target="_blank" rel="nofollow">Lee Wook;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matsika Spiridoula&option=202" target="_blank" rel="nofollow">Matsika Spiridoula;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryTemple UniversityPhiladelphia Pennsylvania 19122 United States;</p> <p>Department of ChemistryTemple UniversityPhiladelphia Pennsylvania 19122 United States;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/1186.html" title="物理化学（理论化学）、化学物理学">物理化学（理论化学）、化学物理学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA&option=203" rel="nofollow">DNA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=electron transfer&option=203" rel="nofollow">electron transfer;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=exciplex&option=203" rel="nofollow">exciplex;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=QM/MM&option=203" rel="nofollow">QM/MM;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=photochemistry&option=203" rel="nofollow">photochemistry;</a> </p> <div class="translation"> 机译：DNA;电子转移;Exciplex;Qm / mm;光化学; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022114560.html">Corrigendum: Photochemical Formation of Cyclobutane Pyrimidine Dimers in DNA through Electron Transfer from a Flanking Base</a> 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class="enjiyixqcontent" href="/academic-journal-cn_journal-chemical-physics_thesis/0201275838912.html">四氯苯醌与嘧啶类核酸碱基的光化学氢抽取和电子转移反应</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘坤辉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘坤辉</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴丽丹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴丽丹</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邹笑然&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邹笑然</a> <span> <a href="/journal-cn-12046/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 化学物理学报 </a> </span> <span> . 2011</span><span> ,第005期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_cancerous-distortion-mutation_thesis/0201267326916.html">不同抗氧化剂在紫外线所致人体皮肤环丁烷嘧啶二聚体形成中 …</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=鄂晓飞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 鄂晓飞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=朱旭东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,朱旭东</a> <span> <a href="/journal-cn-51200/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 癌变．畸变．突变 </a> </span> <span> . 1998</span><span> ,第006期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_imaging-science-photochemistry_thesis/0201232003512.html">四氯苯醌与3β-甲氧基胆甾-5-烯电子转移光化学反应研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨成根&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 杨成根</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴树屏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,吴树屏</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=江致勤&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,江致勤</a> <span> <a href="/journal-cn-10992/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 影像科学与光化学 </a> </span> <span> . 1998</span><span> ,第001期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_spectroscopy-spectral-analysis_thesis/0201232891392.html">DNA介导复合膜中Ru(bpy)32+与Cu(Ⅱ)间光诱导电子转移</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=江臻燊&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 江臻燊</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈敏健&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈敏健</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李红&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李红</a> <span> <a href="/journal-cn-11127/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 光谱学与光谱分析 </a> </span> <span> . 2013</span><span> ,第009期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_spectroscopy-spectral-analysis_thesis/0201232927746.html">VP-16与DNA分子间电子转移的光谱学研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张蕤&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张蕤</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=史钧&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,史钧</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=汪世龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,汪世龙</a> <span> <a href="/journal-cn-11127/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 光谱学与光谱分析 </a> </span> <span> . 2006</span><span> ,第011期</span> </span> 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