Molecular Transformations Using Bis(iodozincio) methane-The Role of Chelation in Main Group Organometallic Chemistry

摘要

The stereoselectivity for the addition of an organometallic reagent to an aldehyde or ketone possessing a Lewis basic atom at the alpha-position can be predicted according to the well-known Chelation Model. Herein we discuss stereoselective reactions of bis(iodozincio) methane, which can coordinate to a heteroatom containing substrate with two zinc atoms in the reagent. Zinc atom coordination in a face-to-face manner to the substrates containing two heteroatoms enables specific molecular recognition, realizing novel molecular transformations.