Facile and Rapid Green Route for the Synthesis of Privileged Peptidotriazoles Based on Oxazolonic Acids by Click Fragment Assembly

摘要

A convenient synthetic pathway to triazole-functionalized oxazolone peptidomimetics by click fragment assembly is described. The target molecules were obtained by the ligation of oxazolone-based peptides with azidopeptides via Cu(I)-catalyzed Huisgen cycloaddition reaction ("Click Chemistry").