Challenges and advances in cleaning ultrafiltration membranes used in bioprocessing

摘要

Proposed is a method to evaluate formulated cleaning agents commonly used for cGMP cleaning applications to demonstrate they may also be suitable for cleaning select ultrafiltration (UF) membranes. Feasibility testing was performed to compare cleaning methodologies, demonstrating a correlation to lab evaluations on a representative surface. Membrane cleaning efficiency was assessed where results indicate use of formulated detergents leads to jncreased cycle lifetime and an average of 40% less water usage for rinsing.