Vitamin E supplementation enhances hemoglobin and erythropoietin levels in mildly anemic adults.

摘要

Increased synthesis of erythropoietin (EPO) occurs mainly in response to relative tissue hypoxia . However, studies in the last few years have suggested many biological factors other than hypoxia, such as thyroid hormone, androgenic steroids, insulin, catalase, progesterone and angiotensin II, which could influence the synthesis and/or secretion of EPO in humans [2-7]. It has been shown in vitro that a combination of antioxidant vitamins (A, C and E) provided to isolated, serum-free, hypoxically perfused rat kidneys significantly increased EPO production . Studies of vitamin E supplementation in hemodialysis patients and children have shown enhanced erythropoiesis and improved levels of hemoglobin [9,10]. Vitamin E, in combination with recombinant human EPO, reduced EPO dosage requirements and enhanced multiplication of erythroid precursor cells [9, 11]. Conflicting results have been reported in children with anemia of prematurity [12], however, a possible role for vitamin E as a human erythropoietic agent in adults with mild anemia has never been reported.