Mitophagie: die gezielte Entsorgung unerwünschter Mitochondrien

摘要

The selective degradation of mitochondria by autophagy, termed mito - phagy, represents an important process required for cell differentiation and removal of damaged mitochondria. Here we review two principle molecular pathways: receptor-mediated and ubiquitin-mediated mito - phagy. The latter pathway was recently linked to the pathogenesis of Parkinson's disease in humans. Recent studies show that such a mechanism that is regulated by ubiquitination and deubiquitination also exists in baker's yeast.