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Sepiolite as a New Nanocarrier for DNA Transfer into Mammalian Cells: Proof of Concept, Issues and Perspectives

机译：Sepiolite作为DNA转移到哺乳动物细胞的新纳米载体：概念，问题和观点的证明

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Abstract >Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier for DNA transfer thanks to its strong interaction with DNA molecules and its ability to be naturally internalized into mammalian cells through both non‐endocytic and endocytic pathways. Sepiolite, due to its ability to bind various biomolecules, could be a good candidate for use as a nanocarrier for the simultaneous vectorization of diverse biological molecules. In this paper, we review our recent work, issued from a starting collaboration with Prof. Ruiz‐Hitzky, that includes diverse aspects on the characterization and main features of sepiolite/DNA nanohybrids, and we present an outlook for the further development of sepiolite for DNA transfer. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> > Sepiolite是一种纳米纤维天然硅酸盐，可用作DNA转移的纳米载体通过非内吞和内吞的途径与DNA分子的强互动及其在哺乳动物细胞中自然内化的能力。由于其染色各种生物分子的能力，Sepiolite可以是用作同时传感器的纳米载体的良好候选者，用于同时为改性的生物分子化。在本文中，我们审查了我们最近的工作，从与Ruiz-Hitzky教授开始合作，其中包括Sepiolite / DNA纳米布麦的表征和主要特征的各种方面，我们提出了对Sepiolite的进一步发展的前景 DNA转移。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16132/'>《Chemical record》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Piétrement Olivier&option=202" target="_blank" rel="nofollow">Piétrement Olivier;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Castro‐Smirnov Fidel Antonio&option=202" target="_blank" rel="nofollow">Castro‐Smirnov Fidel Antonio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Le?Cam Eric&option=202" target="_blank" rel="nofollow">Le?Cam Eric;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Aranda Pilar&option=202" target="_blank" rel="nofollow">Aranda Pilar;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ruiz‐Hitzky Eduardo&option=202" target="_blank" rel="nofollow">Ruiz‐Hitzky Eduardo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lopez Bernard S.&option=202" target="_blank" rel="nofollow">Lopez Bernard S.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>CNRS UMR 8126Université Paris-Sud Université Paris-SaclayGustave Roussy 114 Rue Edouard Vaillant 94805 Villejuif France;</p> <p>CNRS UMR 8200 team labeled “Ligue 2014”Université Paris-Sud Université Paris-SaclayGustave Roussy 114 rue Edouard Vaillant 94805 Villejuif France;</p> <p>CNRS UMR 8126Université Paris-Sud Université Paris-SaclayGustave Roussy 114 Rue Edouard Vaillant 94805 Villejuif France;</p> <p>Instituto de Ciencia de Materiales de Madrid CSICc/ Sor Juana Inés de la Cruz 3 28049 Madrid Spain;</p> <p>Instituto de Ciencia de Materiales de Madrid CSICc/ Sor Juana Inés de la Cruz 3 28049 Madrid Spain;</p> <p>CNRS UMR 8200 team labeled “Ligue 2014”Université Paris-Sud Université Paris-SaclayGustave Roussy 114 rue Edouard Vaillant 94805 Villejuif France;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Clays&option=203" rel="nofollow">Clays;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA&option=203" rel="nofollow">DNA;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sepiolite&option=203" rel="nofollow">Sepiolite;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mammalian Cell transfection&option=203" rel="nofollow">Mammalian Cell transfection;</a> </p> <div class="translation"> 机译：粘土;DNA;海泡石;哺乳动物细胞转染; 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=蔡国平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,蔡国平</a> <span> <a href="/journal-cn-5085/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生物技术通讯 </a> </span> <span> . 2007</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-29463_thesis/020222200882.html">一种新的酵母哺乳动物细胞穿梭载体在不同哺乳动物细胞中的表达</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=冼江&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 冼江</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郑文岭&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郑文岭</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨太成&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨太成</a> <span> <a href="/conference-cn-29463/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第五次全国医学分子微生物学学术研讨会 </a> <span> <span> . 2003</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314504601.html">人釉原蛋白真核表达载体PcDNA3.1-AMG在哺乳动物细胞系及哺乳动物体内表达的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵川江&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 赵川江</a> <span> . 2003</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120104375908.html">使用非哺乳动物DNA病毒在哺乳动物细胞中表达外源基因</a> <b>[P]</b> . <span> 中国专利： CN1172435A </span> <span> . 1998-02-04</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061204507430.html">一种利用ZFN在哺乳动物细胞中实现多个大片段DNA定点整合的方法</a> <b>[P]</b> . <span> 中国专利： CN107217074B </span> <span> . 2021.07.02</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130472530638.html">METHOD FOR COLORING DNA OF LIVING MAMMALIAN CELLS, CELL WITH COLORED DNA, PRONUCLEI COLORING PROCESS, LIVE COLORED MAMMALIAN PRONUCLEAR CELL, METHOD OF REMOVING GENETIC MATTER FROM CELL, GENETIC MATERIAL OBTAINED, PROCESS FOR TRANSFERRING IN PRONUCLEUS, GENETICALLY MODIFIED LIVING MAMMAL CELL, AND PROCESS FOR PRODUCING PHOTOGRAPHIC REPRESENTATION OF SPERMATOZOID MOVEMENT</a> <b>[P]</b> . <span> 外国专利：  FR2550218A1 </span> <span> . 1985-02-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：活体哺乳动物细胞的DNA染色方法，有色DNA的细胞，原核染色过程，活的有色哺乳动物原核细胞，从细胞中去除遗传物质的方法，获得的遗传材料，转移的过程，向母体和母体的遗传过程制作精子运动的照相代表 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130454391872.html">Surfactant mammalian alveolar (mammalian ASP), recombinant DNA, encoding such an ASP, lung surfactant protein encoded by such a DNA, recombinant expression system comprising such a DNA, recombinant host cell transformed with a Such expression system, process for the preparation of mammalian ASP'et using such a cell and ASP frems</a> <b>[P]</b> . <span> 外国专利：  DK172227B1 </span> <span> . 1998-01-12</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：表面活性剂哺乳动物肺泡（哺乳动物ASP），编码此类ASP的重组DNA，由此类DNA编码的肺表面活性剂蛋白，包含此类DNA的重组表达系统，经此类表达系统转化的重组宿主细胞，制备哺乳动物ASP的方法我们使用这样的单元格和ASP框架 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130403958901.html">human transferrin anti-receptor antibody, fusion protein, DNA fragment, expression vector, mammalian cell, pharmacologically active compound and human transferrin anti-receptor antibody complex, uses of human transferrin anti-receptor antibody and fusion protein, and, methods for treating a central nervous system disorder and a central nervous system disorder accompanying pompe disease, hurler syndrome or hurler-scheie syndrome.</a> <b>[P]</b> . <span> 外国专利：  BR112019009316A2 </span> <span> . 2019-08-06</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人运铁蛋白抗受体抗体，融合蛋白，DNA片段，表达载体，哺乳动物细胞，药理活性化合物和人运铁蛋白抗受体抗体复合物，人运铁蛋白抗受体抗体和融合蛋白的用途以及治疗中枢的方法神经系统疾病和中枢神经系统疾病，伴有庞贝病，霍勒综合症或霍勒-谢伊综合症。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" 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