Recent Advances in Organocatalytic Kinetic Resolution for the Synthesis of Functionalized Products

摘要

This Minireview describes organocatalytic kinetic resolution (OCKR) that has evolved on the basis of using small organic catalysts through enamine/iminium ion, N-heterocyclic carbene, and hydrogen-bonding catalysis. The review includes the use of recent methodologies for which the evolution of OCKR mainly involves creating new stereogenic center(s) in functionalized products through the formation of a C-C, C-N, C-O, C-X, or C-S bond. The combination of OCKR with sequential reactions and its association with desymmetrization and dynamic kinetic resolution are also described.