Direct C(sp(2))-H Hydroxylation of Arenes with Palladium(II)/Oxygen Using Sulfoximines as a Recyclable Directing Group

摘要

The aerobic palladium(II) catalysis presented herein offers facile entry to various substituted phenols through site-selective C-H hydroxylation of arenes by using sulfoximines as a reusable directing group. The notable aspects of our method include the use of molecular oxygen (O-2) as the sole oxidant, the activation of molecular oxygen through aldehyde autoxidation, operational simplicity, and the mechanistic studies into the catalytic C-H hydroxylation process.