Synthetic Nucleic Acid Analogues in Gene Therapy: An Update for Peptide–Oligonucleotide Conjugates

Taskova Maria; Mantsiou Anna; Astakhova Kira

摘要

Abstract >The main objective of this work is to provide an update on synthetic nucleic acid analogues and nanoassemblies as tools in gene therapy. In particular, the synthesis and properties of peptide–oligonucleotide conjugates (POCs), which have high potential in research and as therapeutics, are described in detail. The exploration of POCs has already led to fruitful results in the treatment of neurological diseases, lung disorders, cancer, leukemia, viral, and bacterial infections. However, delivery and in vivo stability are the major barriers to the clinical application of POCs and other analogues that still have to be overcome. This review summarizes recent achievements in the delivery and in vivo administration of synthetic nucleic acid analogues, focusing on POCs, and compares their efficiency. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >本工作的主要目的是提供有关合成核酸类似物和纳米组织的更新基因治疗的工具。特别地，详细描述了研究和治疗剂具有高潜力的肽 - 寡核苷酸缀合物（POC）的合成和性质。 POCs的探索已经导致治疗神经疾病，肺病，癌症，白血病，病毒和细菌感染的富有成效的结果。然而，递送和体内稳定性是POCS和其他类似物仍然必须克服的主要障碍。本综述总结了近期递送和体内施用合成核酸类似物的成就，重点介绍了POC，并比较了它们的效率。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16039/'>《Chembiochem: A European journal of chemical biology》</a> <b style="margin: 0 2px;">|</b><span>2017年第17期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Taskova Maria&option=202" target="_blank" rel="nofollow">Taskova Maria;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mantsiou Anna&option=202" target="_blank" rel="nofollow">Mantsiou Anna;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Astakhova Kira&option=202" target="_blank" rel="nofollow">Astakhova Kira;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Nucleic Acid CenterUniversity of Southern DenmarkCampusvej 55 5230 Odense M Denmark;</p> <p>Nucleic Acid CenterUniversity of Southern DenmarkCampusvej 55 5230 Odense M Denmark;</p> <p>Nucleic Acid CenterUniversity of Southern DenmarkCampusvej 55 5230 Odense M Denmark;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=click chemistry&option=203" rel="nofollow">click chemistry;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gene therapy&option=203" rel="nofollow">gene therapy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oligonucleotides&option=203" rel="nofollow">oligonucleotides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=peptides&option=203" rel="nofollow">peptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=synthesis design&option=203" rel="nofollow">synthesis design;</a> </p> <div class="translation"> 机译：点击化学;基因治疗;寡核苷酸;肽;合成设计; 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class="enjiyixqcontent" href="/patent-detail/06120101003764.html">一种可扩展的合成寡核苷酸肽缀合物的操作方法</a> <b>[P]</b> . <span> 中国专利： CN110143997A </span> <span> . 2019-08-20</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130430402869.html">glucagon-like peptide 2 analogue (glp-2) or a pharmaceutically acceptable salt or derivative thereof, pharmaceutical composition, use of a glp-2 analog, nucleic acid molecule, expression vector, host cell, method for the production of glp-2 analog, use of a nucleic acid molecule, an expression vector, or a host cell, methods for treating a stomach and intestinal-related disorder in a patient, for treating or preventing a chemotherapy side effect or radiation therapy to a patient and for treatment of neonatal disorders, obesity, osteoporosis, or dpp-iv mediated conditions, and therapeutic kit</a> <b>[P]</b> . <span> 外国专利：  BRPI0610091A2 </span> <span> . 2008-12-09</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：胰高血糖素样肽2类似物（glp-2）或其药学上可接受的盐或衍生物，药物组合物，glp-2类似物的用途，核酸分子，表达载体，宿主细胞，glp-2类似物的生产方法核酸分子，表达载体或宿主细胞的用途，用于治疗患者的胃和肠道相关疾病，用于治疗或预防对患者的化学疗法副作用或放射疗法以及用于治疗新生儿的方法疾病，肥胖，骨质疏松或dpp-iv介导的疾病和治疗试剂盒 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130447180733.html">Carrier:nucleic acids complexes containing nucleic acids encoding anti-angiogenic peptides and their use in gene therapy</a> <b>[P]</b> . <span> 外国专利：  US2002151516A1 </span> <span> . 2002-10-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含编码抗血管生成肽的核酸的载体：核酸复合物及其在基因治疗中的用途 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130436496086.html">Conjugates of transport of peptides and nucleic acid analogues and their use</a> <b>[P]</b> . <span> 外国专利：  DE69827260T2 </span> <span> . 2006-02-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肽和核酸类似物的转运缀合物及其用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022055698','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img 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