Absence of natriuretic peptide clearance receptor attenuates TGF-1-induced selective atrial fibrosis and atrial fibrillation

摘要

Aims TGF-1 plays an important role in atrial fibrosis and atrial fibrillation (AF); previous studies have shown that the atria are more susceptible to TGF-1 mediated fibrosis than the ventricles. Natriuretic peptides (NPs) play an important role in cardiac remodelling and fibrosis, but the role of natriuretic peptide clearance (NPR-C) receptor is largely unknown. We investigated the role of NPR-C in modulating TGF-1 signalling in the atria.