The surreptitious survival of the emerging pathogen        <fi >Staphylococcus lugdunensis</fi>Staphylococcus lugdunensis        within macrophages as an immune evasion strategy

Flannagan Ronald S.; Watson David W.; Surewaard Bas G. J.; Kubes Paul; Heinrichs David E.

摘要

Abstract > Staphylococcus lugdunensis is a commensal bacterium that can cause serious infection suggesting an ability to circumvent aspects of host immunity. We demonstrate here that macrophages fail to kill ingested S.?lugdunensis and the bacteria persist for extended periods, without replicating, within mature LAMP‐1‐positive phagolysosomes. Phagocytosed S.?lugdunensis also do not intoxicate host cells in contrast to Staphylococcus aureus . Optimal survival of S.?lugdunensis requires O ‐acetylated peptidoglycan because an oatA mutant, which is more sensitive to killing by lysozyme than wild type, survived to a lesser extent in macrophages. In vitro models of macrophage infection reveal that viable intracellular S.?lugdunensis bacteria can be made to grow by pharmacologic perturbation of phagosome function or by phagocyte intoxication by S.?aureus toxins. Remarkably, replicating S.?lugdunensis is not constrained by LAMP‐1 and phosphatidylserine‐positive endomembranes, which is distinct from S.?aureus that replicates within phagolysosomes. In vivo, S.?lugdunensis can also reside in the murine Kupffer cell where the bacteria persist without replicating and require oatA to resist killing in vivo. The intracellular environment of the macrophage represents a niche where S.?lugdunensis can exist while protected from extracellular immune factors and may serve as a reservoir from which these bacteria could disseminate. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 葡萄球菌lugdunensis </ i>是一种值得严重的感染的共生细菌能够规避宿主免疫的方面。我们在此证明，巨噬细胞未能杀死摄入的 s.?Lugdunensis </ i>并且细菌持续到延长的时期，而不复制成熟的灯-1阳性吞噬细胞内。吞噬脂肪酸 s.?Lugddunensis </ i>与金黄色葡萄球菌相比，也不请陶醉宿主细胞。 s.?Lugdunensis的最佳存活率</ i>需要 o </ i> - 乙酰化肽聚糖，因为 oata </ i>突变体，对溶菌酶杀死比野生型更敏感，在巨噬细胞的程度上幸存下来。巨噬细胞感染的体外模型揭示了可行的细胞内 S.?Lugdunensiss（可通过吞噬物质功能的药理扰动或通过 S.?Ureus </ I>毒素的毒素而生长。值得注意的是，复制 S.?Lugdunensis </ i>不受灯-1和磷脂酰丝氨酸阳性端口脲的约束，其与吞噬粒子复制的 S.?UREUS-I>不同。在体内， S.?Lugdunensis </ i>也可以纳入小鼠库普弗细胞，其中细菌在不复制的情况下坚持并且需要 oaata </ i>以抵抗体内杀死。巨噬细胞的细胞内环境代表了在保护细胞外免疫因子的同时存在的乳房，其中可以存在，并且可以用作这些细菌可以散发的储层。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第11期</span><b style="margin: 0 2px;">|</b><span>共16页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flannagan Ronald S.&option=202" target="_blank" rel="nofollow">Flannagan Ronald S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Watson David W.&option=202" target="_blank" rel="nofollow">Watson David W.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Surewaard Bas G. J.&option=202" target="_blank" rel="nofollow">Surewaard Bas G. J.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kubes Paul&option=202" target="_blank" rel="nofollow">Kubes Paul;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Heinrichs David E.&option=202" target="_blank" rel="nofollow">Heinrichs David E.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Microbiology and ImmunologyThe University of Western OntarioLondon Ontario Canada;</p> <p>Department of Microbiology and ImmunologyThe University of Western OntarioLondon Ontario Canada;</p> <p>Department of Medical MicrobiologyUniversity Medical CentreUtrecht The Netherlands;</p> <p>Snyder Institute for Chronic DiseasesUniversity of CalgaryCalgary Alberta Canada;</p> <p>Department of Microbiology and ImmunologyThe University of Western OntarioLondon Ontario Canada;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022032052.html">The surreptitious survival of the emerging pathogen <fi >Staphylococcus lugdunensis</fi>Staphylococcus lugdunensis within macrophages as an immune evasion strategy</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Flannagan Ronald S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Flannagan Ronald S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Watson David W.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Watson David W.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Surewaard Bas G. 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The surreptitious survival of the emerging pathogen Staphylococcus lugdunensisStaphylococcus lugdunensis within macrophages as an immune evasion strategy

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