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首页> 外文期刊>Cellular microbiology >The Rho signalling pathway mediates the pathogenicity of AHPND‐causing V.?parahaemolyticusV.?parahaemolyticus in shrimp
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The Rho signalling pathway mediates the pathogenicity of AHPND‐causing V.?parahaemolyticusV.?parahaemolyticus in shrimp

机译：Rho信号传导途径介导AHPND引起的 V.?PARAHAEMOLYTICUS V.?parahaemolyticus的致病性

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Abstract > An emerging bacterial disease, acute hepatopancreatic necrosis disease (AHPND), is caused by strains of Vibrio parahaemolyticus with an additional AHPND‐associated plasmid pVA1 encoding a virulent toxin (Pir vp ) that damages the shrimp's hepatopancreas. Like other species of Vibrio , these virulent strains initially colonise the shrimp's stomach, but it is not yet understood how the bacteria or toxins are subsequently able to cross the epithelial barrier and reach the hepatopancreas. Here, by using transcriptomics and system biology methods, we investigate AHPND‐induced changes in the stomach of AHPND‐causing V.?parahaemolyticus (5HP)‐infected shrimp and identify host molecular mechanisms that might explain how the integrity of the stomach barrier is compromised. We found that the expression of 376 unique genes was differentially regulated by AHPND infection. Gene ontology, protein interaction, and gene‐to‐gene correlation expression interaction analyses indicated that in addition to the immune system, a number of these genes were involved in cytoskeleton regulation by Rho GTPase. The involvement of Rho pathway regulation during AHPND pathogenesis was further supported by experiments showing that while Rho inhibitor pretreatment delayed the infection, pretreatment with Rho activator enhanced the pathogenicity of 5HP, and both the bacteria and toxin were detected sooner in the hepatopancreas. Further, disruption of the stomach epithelial structure was found in both Rho preactivated shrimp and in 5HP‐infected shrimp. Taken together, we interpret our results to mean that Rho signalling helps to mediate AHPND pathogenesis in shrimp. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>摘录</ title> >出现的细菌疾病，急性肝癌坏死疾病（ahpnd）是由< vibrio parahaemolyticus </ i>具有额外的AHPND相关质粒pVA1，其编码毒力毒素（PIR vp </ i> </ sup>），其损坏虾的肝癌。与其他物种一样，这些毒性菌株最初初始殖民虾的胃，但尚未理解细菌或毒素随后能够穿过上皮屏障并到达肝癌。在这里，通过使用转录组织和系统生物学方法，我们研究了AHPND引起的胃中的AHPND诱导的变化 - 引起的 v.?parahaemolyticus（5HP） - 摄入的虾，并确定了可能解释的宿主分子机制胃屏障的完整性受到损害。我们发现376个独特基因的表达通过AHPND感染差异调节。基因本体，蛋白质相互作用和基因对基因相关表达相互作用分析表明，除了免疫系统之外，还通过RHO GTP酶参与这些基因的许多这些基因。通过实验进一步支持rho途径调节在AHPND发病机制过程中的涉及结果表明，rho抑制剂预处理延迟感染，rho活化剂的预处理增强了5hp的致病性，并且在肝癌中迅速检测到细菌和毒素。此外，在rho失活虾和5HP感染的虾中发现胃上皮结构的破坏。一起携带，我们解释我们的结果，意味着RHO信号传导有助于在虾中调解AHPND发病机制。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ng Tze Hann&option=202" target="_blank" rel="nofollow">Ng Tze Hann;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lu Chia‐Wei&option=202" target="_blank" rel="nofollow">Lu Chia‐Wei;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lin Shih‐Shun&option=202" target="_blank" rel="nofollow">Lin Shih‐Shun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chang Che‐Chih&option=202" target="_blank" rel="nofollow">Chang Che‐Chih;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tran Loc H.&option=202" target="_blank" rel="nofollow">Tran Loc H.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chang Wen‐Chi&option=202" target="_blank" rel="nofollow">Chang Wen‐Chi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lo Chu‐Fang&option=202" target="_blank" rel="nofollow">Lo Chu‐Fang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Han‐Ching&option=202" target="_blank" rel="nofollow">Wang Han‐Ching;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Biotechnology and Bioindustry Sciences College of Biosciences and BiotechnologyNational Cheng Kung UniversityTainan Taiwan;</p> <p>International Center for the Scientific Development of Shrimp AquacultureNational Cheng Kung UniversityTainan 701 Taiwan;</p> <p>Institute of BiotechnologyNational Taiwan UniversityTaipei Taiwan;</p> <p>Department of Biotechnology and Bioindustry Sciences College of Biosciences and BiotechnologyNational Cheng Kung UniversityTainan Taiwan;</p> <p>Department of Aquaculture Pathology College of FisheriesNong Lam UniversityHo Chi Minh City Vietnam;</p> <p>Institute of Tropical Plant Sciences College of Biosciences and BiotechnologyNational Cheng Kung UniversityTainan Taiwan;</p> <p>Department of Biotechnology and Bioindustry Sciences College of Biosciences and BiotechnologyNational Cheng Kung UniversityTainan Taiwan;</p> <p>Department of Biotechnology and Bioindustry Sciences College of Biosciences and BiotechnologyNational Cheng Kung UniversityTainan Taiwan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=AHPND&option=203" rel="nofollow">AHPND;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rho signalling&option=203" rel="nofollow">Rho signalling;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=shrimp&option=203" rel="nofollow">shrimp;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vibrio parahaemolyticus&option=203" rel="nofollow">Vibrio parahaemolyticus;</a> </p> <div class="translation"> 机译：ahpnd;rho信号;虾;vibrio parahaemolyticus; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022032005.html">The Rho signalling pathway mediates the pathogenicity of AHPND‐causing <fi >V.?parahaemolyticus</fi>V.?parahaemolyticus in shrimp</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ng Tze Hann&option=202" target="_blank" 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Aguilar-Rosas</a> <span> <a href="/journal-cn-56204/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 美国植物学期刊（英文） </a> </span> <span> . 2013</span><span>,第12期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-food-industry_thesis/020125051400.html">At Fi EUROPE 2011：Rhodia Aroma Performance will exhibit new branding AND REPOSITIONING OF RHOVANIL＇~ VANILLIN AND RHODIAROME＂ ethyl-vanillinrange HENCEFORTH DEDI- CATED TO THE FOOd INDUSTRY.</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/journal-cn-9437/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国食品工业 </a> </span> <span> . 2011</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_computer-application-abstracts_thesis/0201291601644.html">清除Wi-Fi信号死角 FiberHome R1智能路由器评测</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/journal-cn-8970/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 计算机应用文摘 </a> </span> <span> . 2021</span><span>,第020期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_hebei-medical-journal_thesis/0201288455434.html">RhoA/ROCK-NF-κB信号传导通路介导内脂素诱导的心肌细胞炎性反应机制研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=常亮&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 常亮</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=徐璐&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,徐璐</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘素云&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘素云</a> <span> <a href="/journal-cn-6603/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河北医药 </a> </span> <span> . 2020</span><span>,第024期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-jiangsu-university-medicine-edition_thesis/0201244627296.html">Fis介导伤寒沙门菌滞留菌形成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=颜冬梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 颜冬梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陆仁飞&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陆仁飞</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵昕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵昕</a> <span> <a href="/journal-cn-6504/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 江苏大学学报（医学版） </a> </span> <span> . 2017</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-257_thesis/02022355965.html">p38MAPK信号通路介导HO-1表达对LPS攻击大鼠肺巨噬细胞中线粒体分裂蛋白Fis1的影响</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=康元元&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 康元元</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=史佳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,史佳</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=余剑波&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,余剑波</a> <span> <a href="/conference-cn-257/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2016中国中西医结合麻醉学会（CSIA）年会、第三届全国中西医结合麻醉学术研讨会、河南省中西医结合学会麻醉专业委员会成立大会 </a> <span> <span> . 2016</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312906070.html">Fis介导伤寒沙门菌滞留菌形成的机制研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=颜冬梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 颜冬梅</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113740056.html">利用蛋白酶活化受体介导的信号传导途径的活化来选择具有高效产生细胞外囊泡的能力的干细胞的方法</a> <b>[P]</b> . <span> 中国专利： CN113767166A </span> <span> . 2021-12-07</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06130420228966.html">ШТАМ V. PARAHAEMOLYTICUS № 3Штамм V. Parahaemolyticus</a> <b>[P]</b> . <span> 外国专利： <!-- --> UA76397U </span> <span> . 2013-01-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：V. PARAHAEMOLYTICUS 3号菌株[V. Parahaemolyticus菌株 </span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130427769495.html">МІКРООРГАНІЗМ V. PARAHAEMOLYTICUS ШТАМ № 23-2МИКРООРГАНИЗМ V. PARAHAEMOLYTICUS ШТАММ № 23-2</a> <b>[P]</b> . <span> 外国专利： <!-- --> UA50366U </span> <span> . 2010-06-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：微生物V. PARAHAEMOLYTICUS菌株№23-2 [微生物V. PARAHAEMOLYTICUS菌株№23-2 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130421959353.html">The detection method of V. cholerae, V. parahaemolyticus and V. vulnificus at one try</a> <b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR101119695B1 </span> <span> . 2012-03-12</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：一次尝试检测霍乱弧菌，副溶血弧菌和创伤弧菌 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704022032005','4',7,2,1,'',this,24)" 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