Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial

Liu Licette C. Y.; Valente Mattia A. E.; Postmus Douwe; OConnor Christopher M.; Metra Marco; Dittrich Howard C.; Ponikowski Piotr; Teerlink John R.; Cotter Gad; Davison Beth; Cleland John G. F.; Givertz Michael M.; Bloomfield Daniel M.; van Veldhuisen Dirk J.; Hillege Hans L.; van der Meer Peter; Voors Adriaan A.

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Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial

机译：使用血浆生物标志物在急性心力衰竭中使用血浆生物标志物的不同反应鉴定亚群：保护试验结果

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Background Over the last 50 years, clinical trials of novel interventions for acute heart failure (AHF) have, with few exceptions, been neutral or shown harm. We hypothesize that this might be related to a differential response to pharmacological therapy.

机译：背景技术在过去的50年中，急性心力衰竭（AHF）的新型干预措施的临床试验具有少数例外，是中立的或表现出伤害。我们假设这可能与对药理学疗法的差异反应有关。

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来源
《Cardiovascular drugs and therapy》 |2017年第3期|共13页
作者
Liu Licette C. Y.; Valente Mattia A. E.; Postmus Douwe; OConnor Christopher M.; Metra Marco; Dittrich Howard C.; Ponikowski Piotr; Teerlink John R.; Cotter Gad; Davison Beth; Cleland John G. F.; Givertz Michael M.; Bloomfield Daniel M.; van Veldhuisen Dirk J.; Hillege Hans L.; van der Meer Peter; Voors Adriaan A.;
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作者单位

Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands;

Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands;

Univ Groningen Univ Med Ctr Groningen Dept Epidemiol Groningen Netherlands;

Inova Heart &

Vasc Inst Falls Church VA USA;

Univ Brescia Brescia Italy;

Univ Iowa Carver Coll Med Cardiovasc Res Ctr Iowa City IA USA;

Med Univ Clin Mil Hosp Wroclaw Poland;

Univ Calif San Francisco San Francisco CA 94143 USA;

Momentum Res Durham NC USA;

Momentum Res Durham NC USA;

Imperial Coll London England;

Harvard Med Sch Brigham &

Womens Hosp Boston MA USA;

Merck Res Labs Rahway NJ USA;

Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands;

Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands;

Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands;

Univ Groningen Univ Med Ctr Groningen Dept Cardiol Groningen Netherlands;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Acute heart failure; Treatment heterogeneity; Biomarkers; Subpopulation treatment effect pattern plot; Rolofylline;

机译：急性心力衰竭;治疗异质性;生物标志物;亚潜水素治疗效果图案图;RoRofylline;

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专利

1. Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial [J] . Liu Licette C. Y., Valente Mattia A. E., Postmus Douwe, Cardiovascular drugs and therapy . 2017,第3期

机译：使用血浆生物标志物在急性心力衰竭中使用血浆生物标志物的不同反应鉴定亚群：保护试验结果
2. Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial. [J] . Maisel AS, Mueller C, Fitzgerald R, European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2011,第8期

机译：血浆中性粒细胞明胶酶相关脂质运载蛋白在急性心力衰竭患者中的预后效用：在急性失代偿性心力衰竭（GALLANT）试验中，NGAL评估与B型钠利尿肽一起使用。
3. Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: The NGAL EvaLuationn Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial [J] . Dirk J. van Veldhuisen European Journal of Heart Failure . 2011,第8期

机译：血浆中性粒细胞明胶酶相关脂质运载蛋白在急性心力衰竭患者中的预后效用：NGAL EvaLuationn与B型钠利尿肽一起在急性代偿性心力衰竭（GALLANT）试验中
4. Acute Kidnef Injury Biomarkers and Endpoints for Clinical Trials [C] . PatrickT. Murray Annual International Vicenza Course on Hemodialysis . 2011

机译：急性Kidnef损伤生物标志物和临床试验终点
5. Relation between Biomarkers of Decongestion and Kidney Function with Outcomes in Acute Decompensated Heart Failure [D] . McCallum, Wendy. 2019

机译：急性失代偿心力衰竭成果与肾功能的生物标志物与肾功能的关系
6. Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial [O] . Licette C. Y. Liu, Mattia A. E. Valente, Douwe Postmus, -1

机译：使用血浆生物标志物鉴定对急性心力衰竭治疗反应不同的亚群：PROTECT试验的结果
7. Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial [O] . Liu, Licette C. Y., Valente, Mattia A. E., Postmus, Douwe, 2017

机译：使用血浆生物标志物鉴定对急性心力衰竭治疗反应不同的亚群：PROTECT试验的结果

Identifying Subpopulations with Distinct Response to Treatment Using Plasma Biomarkers in Acute Heart Failure: Results from the PROTECT Trial

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