MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216

Reijers Joannes A. A.; Kallend D. G.; Malone K. E.; Jukema J. W.; Wijngaard P. L. J.; Burggraaf J.; Moerland M.

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MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216

机译：与其前身etc-216相比，MDCO-216不诱导不利免疫刺激

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Aim of this study was to demonstrate that MDCO-216 (human recombinant Apolipoprotein A-I Milano) does not induce adverse immunostimulation, in contrast to its predecessor, ETC-216, which was thought to contain host cell proteins (HCPs) that elicited an inflammatory reaction.

机译：本研究的目的是证明MDCO-216（人重组脂蛋白AI Milano）不诱导不利免疫刺激，与其前身等级216相反，其被认为含有引发炎症反应的宿主细胞蛋白（HCP）。

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来源
《Cardiovascular drugs and therapy》 |2017年第4期|共9页
作者
Reijers Joannes A. A.; Kallend D. G.; Malone K. E.; Jukema J. W.; Wijngaard P. L. J.; Burggraaf J.; Moerland M.;
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作者单位

Ctr Human Drug Res Zernikedreef 8 NL-2333 CL Leiden Netherlands;

Medicines Co Zurich Switzerland;

Good Biomarker Sci Leiden Netherlands;

Leiden Univ Dept Cardiol Med Ctr Leiden Netherlands;

Medicines Co Parsippany NJ USA;

Ctr Human Drug Res Zernikedreef 8 NL-2333 CL Leiden Netherlands;

Ctr Human Drug Res Zernikedreef 8 NL-2333 CL Leiden Netherlands;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Immunostimulation; MDCO-216; ETC-216; Ex vivo stimulation; Apolipoprotein A-I Milano;

机译：免疫刺激;MDCO-216;ETC-216;前体内刺激;载脂蛋白A-I Milano;

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1. MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216 [J] . Reijers Joannes A. A., Kallend D. G., Malone K. E., Cardiovascular drugs and therapy . 2017,第4期

机译：与其前身etc-216相比，MDCO-216不诱导不利免疫刺激
2. Letter to the Editor: how to document adverse reactions induced by gadolinium based contrast agents? A plea for type A and type B reactions [J] . Boehm Ingrid, Lombardo Paolo European radiology . 2020,第3期

机译：致编辑的信：如何记录基于钆的造影剂引起的不良反应？ A型和B型反应的恳求
3. Sometimes neither water nor fire are more useful than friendship—a new risk score for prediction of contrast-induced nephropathy (CIN) and long-term adverse outcomes in patients undergoing coronary angiography [J] . Ovidio De Filippo, Fabrizio D’Ascenzo, Francesco Piroli, Journal of Thoracic Disease . 2019,第7期

机译：有时，水和火都不比友谊更有用-这是预测接受冠状动脉造影术的造影剂肾病（CIN）和长期不良结局的新危险评分
4. EARLY IMMUNOSTIMULATION OF LITOPENAEUS VANNAMEI SHRIMP TO INDUCE A HIGHER IMMUNE RESPONSE TO WHITE SPOT SYNDROME VIRUS (WSSV) [C] . J. Rodriguez, Y. Espinosa, F. Echeverria, International Conference of the European Aquaculture Society . 2004

机译：Litopenaeus vannamei虾的早期免疫刺激诱导白斑综合征病毒（WSSV）的更高免疫应答
5. Involvement of Th17 Pathway in Adverse Drug Reactions: Mechanistic Investigation of Drug-Induced Autoimmunity and Drug-induced Liver Injury. [D] . Zhu, Ervin Xu. 2012

机译：Th17途径参与药物不良反应：药物诱发的自身免疫和药物诱发的肝损伤的机制研究。
6. MDCO-216 Does Not Induce Adverse Immunostimulation in Contrast to Its Predecessor ETC-216 [O] . Joannes A. A. Reijers, D. G. Kallend, K. E. Malone, -1

机译：与先前的ETC-216相比MDCO-216不会产生不利的免疫刺激作用
7. Differences between Drug-Induced and Contrast Media-Induced Adverse Reactions Based on Spontaneously Reported Adverse Drug Reactions. [O] . JiHyeon Ryu, HeeYoung Lee, JinUk Suh, 2015

机译：基于自发报告的不良药物反应的药物诱导和对比介质诱导的不良反应之间的差异。

MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216

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