Calling attention to radiation recall reactions. Simultaneous occurrence of a Recall Dermatitis after CMF application in two separate sites irradiated 10 years apart

摘要

Since the discovery and the first therapeutic use of x-rays in 1895, radiation-induced skin reactions are well known side effects of radiotherapy (RT). Aetio-logical background is the radiation-induced damage to the germinative cells of the epidermis and its appendages. Due to the increasing use of established and recently developed systemic agents administered during and/or after RT, such interactions gain in importance. Among these, radiation recall reactions (RRR) occurring in skin, mucosa and internal organs are uncommon and a poorly understood phenomenon, that neither belong to acute nor to chronic radiation reactions.