Physiologie, Pharmakologie und neue Ans?tze für die Therapie der Allergie

摘要

Histamine H_1 -receptor-selective antagonists play an important role in the therapy of allergic rhinitis and conjunctivitis but not in allergic asthma. In asthma, the histamine H_4 receptor seems to be a promising therapeutic target. Important experimental tools are H_4 receptor knockout mice and H_4 receptor antagonists blocking the action of histamine. With H_4 receptor knockout mice, the contributions of individual cell types in asthma pathogenesis can be dissected.