Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours

Nebot Noelia; Arkenau Hendrik-Tobias; Infante Jeffrey R.; Chandler Jason C.; Weickhardt Andrew; Lickliter Jason D.; Sarantopoulos John; Gordon Michael S.; Mak Gabriel; St-Pierre Annie; Tang Lihua; Mookerjee Bijoyesh; Carson Stanley W.; Hayes Siobhan; Grossmann Kenneth F.

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Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours

机译：Dabrafenib和代谢产物对BRAF v600-突变肿瘤患者QTC间隔的影响

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摘要

AimsThe effect of repeat oral supratherapeutic dosing of the BRAF inhibitor dabrafenib on QTc interval was assessed in patients with BRAF V600-mutant tumours.

机译：BRAF V600-突变肿瘤的患者评估了BRAF抑制剂DabrafeN的重复口服Supratherapeutic剂量对QTC间隔的影响。

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来源
《British Journal of Clinical Pharmacology》 |2018年第4期|共12页
作者
Nebot Noelia; Arkenau Hendrik-Tobias; Infante Jeffrey R.; Chandler Jason C.; Weickhardt Andrew; Lickliter Jason D.; Sarantopoulos John; Gordon Michael S.; Mak Gabriel; St-Pierre Annie; Tang Lihua; Mookerjee Bijoyesh; Carson Stanley W.; Hayes Siobhan; Grossmann Kenneth F.;
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作者单位

Novartis Pharmaceut One Hlth Plaza Bldg 337 E Hanover NJ 07936 USA;

Sarah Cannon Res Inst London W1G 6AD England;

Sarah Cannon Res Inst Nashville TN 37203 USA;

West Canc Ctr Memphis TN USA;

Austin Hlth Olivia Newton John Canc Wellness &

Res Ctr Heidelberg Vic Australia;

Nucleus Network Melbourne Vic 3004 Australia;

Univ Texas Hlth Sci Ctr San Antonio Inst Drug Dev Canc Therapy &

Res Ctr San Antonio TX 78229;

HonorHlth Res Inst Pinnacle Oncol Hematol Scottsdale AZ 85258 USA;

Sarah Cannon Res Inst UK London W1G 6AD England;

Novartis Pharma AG Basel Switzerland;

Novartis Pharmaceut Morrisville NC USA;

Novartis Pharmaceut One Hlth Plaza Bldg 337 E Hanover NJ 07936 USA;

Novartis Pharmaceut Morrisville NC USA;

ICON Marlow Bucks England;

Huntsman Canc Inst Salt Lake City UT 84112 USA;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
drug safety; oncology; pharmacodynamics; pharmacokinetics; QT prolongation;

机译：药物安全;肿瘤学;药效学;药代动力学;QT延长;

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1. Combination therapy of dabrafenib plus trametinib in patients with BRAF V600E -mutated biliary tract cancer [J] . Alessandro Rizzo, Angela Dalia Ricci, Giovanni Brandi 国际肝胆胰疾病杂志（英文版） . 2021,第005期
2. Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours [J] . Nebot Noelia, Arkenau Hendrik-Tobias, Infante Jeffrey R., British Journal of Clinical Pharmacology . 2018,第4期

机译：Dabrafenib和代谢产物对BRAF v600-突变肿瘤患者QTC间隔的影响
3. Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib monotherapy: Analysis from phase 2 and 3 clinical trials [J] . Hauschild Axel, Ascierto Paolo A., Schadendorf Dirk, European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2020,第1期

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4. Dabrafenib and Trametinib Treatment in Patients With Locally Advanced or Metastatic BRAF V600-Mutant Anaplastic Thyroid Cancer [J] . Subbiah Vivek, Kreitman Robert J., Wainberg Zev A., Journal of Clinical Oncology . 2018,第1期

机译：Dabrafenib和Trametinib在局部晚期或转移BRAF V600-突变体内甲状腺癌患者的治疗方法
5. Discrimination of herg carrier from non-carrier adult patients with borderline prolonged QTc interval [C] . Couderc, J.P., Zareba, . 2005

机译：边缘性QTc间隔延长的非携带者成人患者与Herg携带者的区别
6. A pilot study to evaluate KLK6 as a biomarker for the detection of circulating tumour cells in ovarian cancer patients. [D] . Oikonomopoulou, Aikaterini. 2004

机译：一项评估KLK6作为检测卵巢癌患者循环肿瘤细胞生物标志物的初步研究。
7. Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600–mutant tumours [O] . Noelia Nebot, Hendrik‐Tobias Arkenau, Jeffrey R. Infante, 2018

机译：评估dabrafenib和代谢物对BRAF V600突变型肿瘤患者QTc间隔的影响
8. Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours [O] . Noelia Nebot, Hendrik-Tobias Arkenau, Jeffrey R. Infante, 2018

机译：Dabrafenib和代谢产物对BRAF v600-突变肿瘤患者QTC间隔的影响

Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with BRAF V600-mutant tumours

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