Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery

Gertler Ralph; Gruber Michael; Grassin-Delyle Stanislas; Urien Saik; Martin Klaus; Tassani-Prell Peter; Braun Siegmund; Burg Simon; Wiesner Gunther

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Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery

机译：新生儿和婴幼儿中旱生酸的药代动力学

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AimTranexamic acid (TXA) continues to be one of the antifibrinolytics of choice during paediatric cardiac surgery. However, in infants less than 1year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion.

机译：艾司丹蛋白酸（TXA）仍然是在儿科心脏手术期间选择的抗纤维蛋白溶解剂之一。然而，在低于1年龄的婴儿中，基于药代动力学（PK）考虑的最佳给药仍在讨论中。

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来源
《British Journal of Clinical Pharmacology》 |2017年第8期|共13页
作者
Gertler Ralph; Gruber Michael; Grassin-Delyle Stanislas; Urien Saik; Martin Klaus; Tassani-Prell Peter; Braun Siegmund; Burg Simon; Wiesner Gunther;
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作者单位

Univ Med Ctr Hamburg Eppendorf Klinikum Links Weser Klin Anaesthesie Operat Allgemeine;

Univ Hosp Regensburg Dept Anesthesia Regensburg Germany;

Univ Paris Saclay Univ Versailles St Quentin en Yvelines Hop Foch Dept Malad Voies Resp F-92150;

URC Paris Descartes Necker Cochin AP HP CIC1419 Inserm Necker Cochin Paris France;

Tech Univ Munich Inst Anaesthesiol German Heart Ctr Munich Munich Germany;

Tech Univ Munich Inst Anaesthesiol German Heart Ctr Munich Munich Germany;

Tech Univ Munich Inst Lab Med German Heart Ctr Munich Munich Germany;

Tech Univ Munich Inst Anaesthesiol German Heart Ctr Munich Munich Germany;

Tech Univ Munich Inst Anaesthesiol German Heart Ctr Munich Munich Germany;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
tranexamic acid; antifibrinolytic agents; pharmacokinetics; cardiac surgical procedures; congenital heart defects;

机译：Tranexamic酸;抗纤二溶胶;药代动力学;心脏外科手术;先天性心脏缺陷;

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专利

1. Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery [J] . Ralph Gertler, Michael Gruber, Stanislas Grassin‐Delyle, British journal of clinical pharmacology . 2017,第8期

机译：氨甲环酸在新生儿和婴儿心脏手术中的药代动力学
2. Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery [J] . Gertler Ralph, Gruber Michael, Grassin-Delyle Stanislas, British Journal of Clinical Pharmacology . 2017,第8期

机译：新生儿和婴幼儿中旱生酸的药代动力学
3. Pharmacokinetics of Tranexamic Acid in Neonates, Infants, and Children Undergoing Cardiac Surgery with Cardiopulmonary Bypass [J] . Wesley Mark C., Pereira Luis M., Scharp Laurie A., Anesthesiology . 2015,第4期

机译：氨甲环酸在新生儿，婴儿和接受心脏外科手术并经过心肺旁路手术的儿童中的药代动力学
4. SOLID PHASE MICROEXTRACTION COUPLED TO MASS SPECTROMETRY VIA MICROFLUIDIC OPEN INTERFACE FOR POINT-OF-CARE TESTING OF TRANEXAMIC ACID IN PLASMA OF CARDIAC SURGICAL PATIENTS [C] . Nikita Looby, Marcos Tascon, Vinicius Acquaro, International Mass Spectrometry Conference . 2018

机译：通过微流体开放界面耦合到质谱耦合到质谱法，用于心脏手术患者血浆中促甲酸的护理点测试
5. A retrospective analysis of nutritional status, length of hospital stay, and ventilatory status for infants and children undergoing surgery for congenital heart lesions at Rush Presbyterian-St. Luke's Medical Center (Illinois). [D] . Gerbeling, Teresa Marie. 2001

机译：对Rush Presbyterian-St进行先天性心脏病手术的婴幼儿的营养状况，住院时间和通气状况进行回顾性分析。卢克医学中心（伊利诺伊州）。
6. Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery [O] . Ralph Gertler, Michael Gruber, Stanislas Grassin‐Delyle, 2017

机译：氨甲环酸在新生儿和婴儿心脏手术中的药代动力学
7. Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery [O] . Ralph Gertler, Michael Gruber, Stanislas Grassin-Delyle, 2017

机译：新生儿和婴幼儿中旱生酸的药代动力学

Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery

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