Short term exposure to oxycodone alters the survival, proliferation and differentiation of rat embryonic neural stem cell in vitro

摘要

As one of several opioids, oxycodone has been widely used, particularly in postoperative analgesia in children and cesarean section. However, the effect of oxycodone on developing brain still remains to be seen. Since there is a link between anesthetics exposure and long-term behavioral or cognitive dysfunction in young children, in the current study, the direct effect of oxycodone on neural stem cells (NSCs) biological behaviors was investigated. After exposed to a high dose of oxycodone (10?μg/mL) for 48?h, NSCs survival and proliferation were significantly reduced, while NSCs apoptosis and differentiation were enhanced. These effects were significantly weaker than that when exposed to same dose of morphine. No significant difference was observed regarding to above biological behaviors when exposed to lower doses (0.1?μg/mL and 1.0?μg/mL) of oxycodone. The antagonist of opioid receptor, nalmefene, successfully reversed the influence of oxycodone. Taken together, our results indicated that short term exposure to oxycodone in low dose might be allowed for developing brain.